Publikationsverzeichnis

Prof. Dr. rer. nat. Jürgen Löffler

Ausgewählte Publikationen

– Mengoli, C., Cruciani M,. Barnes R.A., Loeffler J., Donnelly, P.” A systematic review and meta-analysis of Polymerase chain Reaction for diagnosing invasive aspergillosis”. 2009, Lancet Infectious Diseases, 2: 89-96

– Bouzani M., Ok M., McCormick A., Ebel F., Kurzai O., Morton O., Einsele H., Loeffler J. “Human NK cells display important antifungal activity against Aspergillus fumigatus, which is directly mediated by Interferon gamma release”. 2011, Journal of Immunology, 187: 1369-1375

– Bouzani M., Einsele H., Loeffler J. „Functional analysis is a paramount prerequisite for understanding the in vitro interaction of human Natural Killer cells with Aspergillus fumigatus“. 2012, Journal of Infectious Diseases, 205: 1025-1026

– Voigt J., Huenniger K., Bouzani M., Jacobsen I., Barz D., Hube B., Löffler J., Kurzai O. “Human NK cells act as phagocytes against Candida albicans and mount an inflammatory response which modulates neutrophil antifungal activity”. 2014, Journal of Infectious Diseases, 209: 616-626

– Cunha C., Aversa F., Lacerda J., Busca A., Kurzai O., Grube M., Löffler J., Maertens J., Bell A., Inforzato A., Barbati E., Almeida B., Santos e Sousa P., Barbui A., Potenza L., Caira M., Rodrigues F., Salvatori G., Pagano L., Luppi M., Mantovani A., Velardi A., Romani L., Carvalho A. “Genetic PTX3 deficiency and aspergillosis in stem cell transplantation”. 2014, New England Journal of Medicine 370: 421-432

– Hünniger K., Bieber K., Martin R., Lehnert T., Figge T., Löffler J., Guo R., Riedemann N., Kurzai O. „A second stimulus required for enhanced antifungal activity of human neutrophils in blood is provided by anaphylatoxin C5a“. 2015, Journal of Immunology, 194: 1199-1210

– Rieber N., Singh A., Carevic M., Öz H., Bouzani M., Amich J., Ost M., ye, Z., Schäfer I., Mezger M., Klimosch S., Weber A., Handgretinger R., Liese J., Engeholm M., Schüle R., Salih H., Marodi L., Speckmann C., Grimbacher B., Ruland J., Brown G., Beilhack A., Loeffler J., Hartl D. “Pathogenic fungi regulate T-cell immunity by including neutrophil myeloid-derived suppressor cells through a dectin-1 / CARD9 and ROS-mediated mechanisms”. 2015, Cell Host and Microbe, 17: 507-514

– Leonhardt I., Spielberg S., Weber M., Albrecht-Eckardt D., Bläss M., Claus R., Barz D., Löffler J., Hünniger K., Kurzai O. “The fungal Quorum-Sensing-Molecule Farnesol activates innate immune cells but suppresses cellular adaptive immunity”, 2015, MBio, 6: e00143

– Czakai K., Leonhardt I., Dix A., Bonin M., Linde J., Einsele H., Kurzai O., Loeffler J. “Krüppel-like Factor 4 modulates interleukin-6 release in human dendritic cells after in vitro stimulation with Aspergillus fumigatus and Candida albicans”. 2016, Scientific Reports 6: 27990

– Ziegler S., Weiss E., Schmitt A., Schlegel J., Burgert A., Terpitz U., Sauer M., Moretta L., Sivori S., Leonhardt I., Kurzai O., Einsele H., Loeffler J. “CD56 Is a Pathogen Recognition Receptor on Human Natural Killer Cells”. 2017, Scientific Reports, 7: 6138

– Hellmann A., Lother J., Wurster S., Lutz M., Schmitt1 A., Morton O., Eyrich M., Czakai K., Einsele H., Loeffler J. „Human and murine innate immune cell populations display common and distinct response patterns during their in vitro interaction with the pathogenic mould Aspergillus fumigatus”, 2017, Frontiers in Immunology, in press

 

Wissenschftliche Orginalarbeiten

1. Einsele H., Ehninger G., Hebart H., Wittkowski K.M., Schuler U., Jahn G., Mackes P., Herter M., Klingebiel T., Löffler J., Wagner S., Müller C.A. Polymerase chain reaction reduces the incidence of cytomegalovirus disease and the duration and side effects of antiviral therapy after bone marrow transplantation. 1995, Blood, 86: 2815-2820

2. Löffler J., Schumacher U., Hebart H., Reitze H., Einsele H. Extraction of fungal DNA from cultures and blood using the QIAamp Tissue Kit. 1996, Qiagen News, 4/96: 16-17,

3. Hebart H., Müller C.A., Löffler J., Jahn G., Einsele H. Monitoring of CMV infection: a comparison of PCR from whole blood, plasma-PCR, pp65 antigenemia and virus culture in patients after bone marrow transplantation. 1996, Bone Marrow Transplantation, 17: 861-868

4. Kelly S.L., Lamb D.C., Kelly D.E., Loeffler J., Einsele H. Resistance to fluconazole and amphotericin B in Candida albicans from AIDS patients. 1996, Letter to Lancet, 348: 1523-1524,

5. Löffler J., Kelly S.L., Hebart H., Schumacher U., Lass-Floerl C., Einsele H. Molecular analysis of CYP51 from fluconazole-resistant Candida albicans strains. 1997, FEMS Microbiology Letters, 151: 263-268

6. Löffler J., Hebart H., Schumacher U., Reitze H., Einsele H. Comparison of different methods for fungal DNA extraction from cultures and blood. 1997, Journal of Clinical Microbiology, 35: 3311-3312

7. Kelly S.L., Lamb D.C., Kelly D.E., Manning N.J., Loeffler J., Hebart H., Schumacher U., Einsele H. Resistance to fluconazole and cross-resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol Δ5,6 desaturation. 1997, FEBS Letters, 400: 80-82

8. Hebart H., Schröder A., Löffler J., Klingebiel T., Martin H., Wassmann B., Gerneth F., Rabenau H., Jahn G., Kanz L., Müller C.A., Einsele H. Cytomegalovirus monitoring by polymerase chain reaction of whole blood samples from patients undergoing autologous bone marrow or peripheral blood progenitor cell transplantation. 1997, Journal of Infectious Diseases 175: 1490-1493

9. Einsele H., Hebart H., Roller G., Löffler J., Rothenhöfer I., Müller C.A., Bowden R.A., van Burik J.A., Engelhard D., Kanz L., Schumacher U. Detection and identification of fungal pathogens in blood by using molecular probes. 1997, Journal of Clinical Microbiology, 35: 1353-1360

10. Loeffler J., Hebart H., Sepe S., Schumacher U., Klingebiel T., Einsele H. Detection of PCR-amplified fungal DNA by using a PCR-ELISA system. 1998, Medical Mycology, 36: 275-279

11. Hebart H., Löffler J., Jahn G., Einsele H. Reply to Kawasaki et al., „Cytomegalovirus monitoring by culture of urine and throat swabs from Japanese children undergoing autologous bone marrow or peripheral blood progenitor or allogeneic bone marrow transplantation”, Reply – JID A 970873. 1998, Journal of Infectious Diseases, 177: 519-520

12. Hebart H., Gamer D., Loeffler J., Müller C.A., Sinzger C., Jahn G., Bader P., Klingebiel T., Kanz L., Einsele H. Evaluation of Murex CMV DNA hybrid capture assay for detection and quantitation of cytomegalovirus infection in patients following allogeneic stem cell transplantation. 1998, Journal of Clinical Microbiology, 36: 1333-1337

13. Einsele H., Quabeck K., Müller K.D., Hebart H., Rothenhöfer I., Löffler J., Schaefer U.W. Prediction of invasive pulmonary aspergillosis from colonization of the lower respiratory tract before marrow transplantation. 1998, Letter to Lancet, 352: 1443

14. Loeffler J., Hebart H., Bialek R., Hagmeyer L., Schmidt D., Serey F.P., Hartmann M., Eucker J., Einsele H. Contaminations occuring in fungal PCR assays. 1999, Journal of Clinical Microbiology, 37: 1200-1202

15. Löffler J., Einsele H., Hebart H., Schumacher U., Hrastnik C., Daum G. Phospholipid and sterol analysis of plasma membranes of azole-resistant Candida albicans strains. 1999, FEMS Microbiology Letters, 185: 59-63

16. Loeffler J., Hagmeyer H., Hebart H., Henke H., Schumacher U., Einsele H. Rapid detection of point mutations by fluorescence resonance energy transfer and probe melting curves in Candida species. 2000, Clinical Chemistry, 46: 631-635

17. Kelly S.L., Lamb D.C., Loeffler J., Einsele H., Kelly D.E. The G464S amino acid substitution in Candida albicans sterol 14α-demethylase causes fluconazole resistance in the clinic through reduced affinity. 1999, Biochemical and Biophysical Research Communications, 262: 174-179

18. Loeffler J., Hagmeyer H., Hebart H., Henke H., Schumacher U., Einsele H. Rapid detection of point mutations by fluorescence resonance energy transfer and probe melting curves in Candida species. 2000, Clinical Chemistry, 46: 631-635,

19. Einsele H., Hebart H., Kauffmann-Schneider C., Sinzger C., Jahn G., Bader P., Klingebiel T., Dietz K., Löffler J., Bokemeyer C., Müller C., Kanz L. Risk factors for treatment failures in patients receiving PCR-based preemptive therapy for CMV infection. 2000, Bone Marrow Transplantation, 25: 757-763

20. Loeffler J., Henke H., Hebart H., Schmidt D., Hagmeyer H., Schumacher U., Einsele H. Quantification of fungal DNA by using fluorescence resonance energy transfer and the LightCycler system. 2000, Journal of Clinical Microbiolgy, 38: 586-590

21. Loeffler J., Hebart H., Brauchle U., Schumacher U., Einsele H. Comparison between plasma and whole blood specimens for detection of Aspergillus DNA by PCR. 2000, Journal of Clinical Microbiology, 38: 3830-3833

22. Loeffler J., Hebart H., Magga S., Schmidt D., Klingspor L., Tollemar J., Schumacher U., Einsele H. Identification of rare Candida species and other yeasts by polymerase chain reaction and slot blot hybridization. 2000, Diagnostic Microbiology and Infectious Diseases, 38: 207-212

23. Hebart H., Löffler J., Reitze H., Engel A., Schumacher U., Klingebiel T., Bader P., Böhme A., Martin H., Bunjes D., Kern W.V., Kanz L., Einsele H. Prospective screening by a panfungal polymerase chain reaction assay in patients at risk for fungal infections: implications for the management of febrile neutropenia. 2000, British Journal of Haematology, 111: 635-640

24. Hebart H., Löffler J., Meisner C., Serey F., Schmidt D., Böhme A., Martin H., Engel A., Bunjes D., Kern W.V., Schumacher U., Kanz L., Einsele H. Early detection of Aspergillus infection after allogeneic stem cell transplantation by polymerase chain reaction screening. 2000, Journal of Infectious Diseases, 181: 1713-1719

25. Hebart H., Loeffler J., Kanz L., Einsele H. Molecular methods in the diagnosis of infections in the immunocompromised host. 2000, Current Opinion in Infectious Diseases, 13: 355-359

26. Loeffler J., Hebart H., Cox P., Flues N., Schumacher U., Einsele H. Nucleic acid sequence-based amplification of Aspergillus RNA in blood samples. 2001, Journal of Clinical Microbiology, 39: 1626-1629

27. Hebart H., Brugger W., Grigoleit U., Gscheidle B., Loeffler J., Schäfer H.J.., Kanz L., Einsele H. Risk for Cytomegalovirus disease in patients receiving polymerase chain reaction-based preemptive antiviral therapy after allogeneic stem cell transplantation depends on transplantation modality. 2001, Correspondence to Blood, 97: 2183-2185

28. Hebart H., Wuchter P., Loeffler J., Gscheidle B., Hamprecht K., Sinzger C., Jahn G., Dietz K., Kanz L., Einsele H. Evaluation of the Murex CMV DNA Hybrid Capture assay (version 2.0) for early diagnosis of cytomegalovirus infection in recipients of an allogeneic stem cell transplant. 2001, Bone Marrow Transplantation, 28: 213-218,

29. Rickerts V., Loeffler J., Böhme A., Einsele H., Just-Nübling G. Diagnosis of disseminated zygomycosis using a polymerase chain reaction assay. 2001, European Journal of Clinical Microbiology and Infectious Diseases, 20: 744-745

30. Loeffler J., Kloepfer K., Hebart H., Najvar L., Graybill J.R., Kirkpatrick W.R., Patterson T.F., Dietz K., Bialek R., Einsele H. Polymerase chain reaction detection of Aspergillus-DNA in experimental models of invasive Aspergillosis. 2002, Journal of Infectious Diseases, 185: 1203-1206

31. Loeffler J., Schmidt K., Hebart H., Schumacher U., Einsele H. Automated extraction of genomic DNA from medically important yeast species and filamentous fungi by using the MagNAPure LC system. 2002, Journal of Clinical Microbiology, 40: 2240-2243

32. Loeffler J., Bauer R., Hebart H., Douek D.C., Rauser G., Bader P., Einsele H. Quantification of T-cell receptor excision circle DNA using fluorescence resonance energy transfer and the LightCycler system. 2002, Journal of Immunological Methods, 271: 167-175

33. Hebart H., Daginik S., Stevanovic S., Grigoleit U., Dobler A., Baur M., Rauser G., Sinzger C., Jahn G., Loeffler J., Kanz L., Rammensee H.G., Einsele H. Sensitive detection of human cytomegalovirus peptide-specific cytotoxic T-lymphocyte responses by interferon-gamma-enzyme-linked immunospot assay and flow cytometry in healthy individuals and in patients after allogeneic stem cell transplantation. 2002, Blood, 99: 3830-3837

34. Einsele H., Roosnek E., Rufer N., Sinzger C., Riegler S., Löffler J., Grigoleit U., Moris A., Rammensee H.G., Kanz L., Kleihauer A., Frank F., Jahn G., Hebart H. Infusion of Cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy. 2002, Blood, 99: 3916-3922,

35. Hebart H., Bollinger C., Fisch, P., Sarfati J., Meisner C., Baur M., Loeffler J., Monod M., Latge JP., Einsele H. Analysis of T-cell responses to Aspergillus fumigatus antigens in healthy individuals and patients with hematological malignancies. 2002, Blood, 100: 4521-4528

36. Hebart H., Rudolph T., Loeffler J., Middeldorp J., Ljubicic T., Jahn G., Einsele H. Evaluation of the Nuclisens CMV pp67 assay for detection and monitoring of human cytomegalovirus infection after allogeneic stem cell transplantation. 2002, Bone Marrow Transplantation, 30: 181-187

37. Von Müller L., Hampl W., Hinz J., Meisel H., Reip A., Engelmann E., Heilbronn R., Gärtner B., Krämer O., Einsele H., Hebart H., Ljubicic T., Löffler J., Mertens T. High variability between results of different in house tests for cytomegalovirus monitoring and a standardized quantitative plasma CMV PCR assay. 2002, Journal of Clinical Microbiology, 40: 2285-2287

38. Loeffler J., Dorn C., Hebart H., Cox P., Magga S., Einsele H. Development and evaluation of the Nuclisens Basic Kit NASBA for the detection of RNA from Candida species frequently resistant to antifungal drugs. 2003, Diagnostic Microbiology and Infectious Diseases, 45: 217-220

39. Loeffler J., Swatoch P., Akhawi-Araghi D., Hebart H., Einsele H. Automated RNA extraction by MagNAPure followed by rapid quantification of cytokine and chemokine gene expression with use of fluorescence resonance energy transfer. 2003, Clinical Chemistry, 49: 955-958

40. Kuci S., Wessels JT., Bühring HJ., Schilbach K., Schumm M., Seitz G., Löffler J., Bader P., Schlegel PG., Niethammer D., Handgretinger R. Identification of a novel class of human adherent CD34stem cells that give rise to SCID-repopulating cells. 2003, Blood, 101: 869-876

41. Hebart H., Rauser G., Stevenovic S., Haenle C., Nussbaum A.K., Meisner C., Bissinger A.L., Tenzer S., Jahn G., Loeffler J., Rammensee H.G., Schild H., Einsele H. A CTL epitope from human cytomegalovirus IE1 defined by combining prediction

of HLA binding and proteasomal processing is the target of dominant immune responses in patients after allogeneic stem cell transplantation. 2003, Experimental Hematology 31: 966-973

42. Waidmann M., Bechtold O., Frick J.S., Lehr H.A., Schubert S., Dobrindt U., Löffler J., Bohn E., Autenrieth I.B. Bacteroides vulgatus protects against Escherichia coli induced colitis in gnotobiotic interleukin-2 deficient mice. 2003, Gastroenterology, 125: 162-177

43. Braedel S., Radsak M., Einsele H., Latgé J., Michan A., Loeffler J., Haddad Z., Grigoleit U., Schild H., Hebart H. “Aspergillus fumigatus antigens activate innate immune cells via toll-like receptors 2 and 4.”. 2004, British Journal of Haematology 125: 392-399

44. Bissinger A.L., Einsele H., Hamprecht K., Schumacher U., Kandolf R., Loeffler J., Aepinus C., Bock, T., Jahn G., Hebart H. “Infectious pulmonary complications after stem cell transplantation or chemotherapy: Diagnostic yield of bronchoalveolar lavage”. 2005, Diagnostic Microbiology and Infectious Diseases 52: 277 – 280

45. Kötter I., Daikeler T., Einsele H., Koch S., Lochmann L., Kanz L., Loeffler J. “Relapse of autoimmune diseases after autologous T cell depleted stem cell transplantation may be triggered by T cells recently emigrated from the thymus”. 2005, Annals of the Rheumatic Diseases 64: 1787 – 1789

46. Loeffler J., Steffens M., Arlt E.M., Toliat M.R., Mezger M., Suk A., Wienker T.F., Hebart H., Nurnberg P., Boeckh M., Ljungman P., Trenschel R., Einsele H. “Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10 and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation”. 2006, Journal of Clinical Microbiology 44: 1847 – 1850

47. Gille C., Spring B., Tewes L., Loeffler J., Dannecker G.E., Hoffmann M.K., Eichner M., Poets C.F., Orlikowsky T.W. “Diminished response to Interleukin-10 and reduced antibody-dependent cellular cytotoxicity of cord blood monocyte-derived macrophages”. 2006, Pediatric Research 60: 153 – 158

48. Lengerke C., Ljubicic T., Meisner C., Loeffler J., Sinzger C., Einsele H., Hebart H. „Evaluation of the COBAS Amplicor HCMV Monitor for early detection and monitoring of human cytomegalovirus infection after allogeneic stem cell transplantation”. 2006, Bone Marrow Transplantation 38: 53-60

49. Staab A., Loeffler, J., Said H.M., Katzer A., Beyer M., Polat B., Einsele H., Flentje M., Vordermark D. “Modulation of glucose metabolism inhibits hypoxic accumulation of hypoxia-inducible fator-1α (HIF-1α)”. 2007, Strahlentherapie und Onkologie 183: 366-373

50. Staab A., Loeffler J., Said H.M., Diehlmann D., Katzer A., Beyer M., Fleischer M., Schwab F., Baier K., Einsele H., Flentje M., Vordermark D. “Effects of HIF-1 inhibition by chemotin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells”. 2007, BMC Cancer 7: 213

51. Mezger M., Steffens M., Beyer M., Manger C., Eberle J., Toliat M.R., Wienker T.F., Ljungman P., Hebart H., Dornbusch H.J., Einsele H., Loeffler J. “Polymorphisms in the chemokine (C-X-C motif) ligand 10 are associated with invasive aspergillosis after allogeneic stem cell transplantation and influence CXCL10 expression in monocyte-derived dendritic cells”. 2008, Blood, 111: 534-536

52. Wozniok I., Bach A., Schmitt C., Frosch M., Einsele H., Hube B., Loeffler J., Kurzai O. “Induktion of ERK-kinase signaling triggers morphotype-specific killing of Candida albicans filaments by human neutrophils”. 2007, Cellular Microbiology, 10: 807-820

53. Lessing F., Kniemeyer O., Wozniok I., Loeffler J., Kurzai O., Haertl A., Brakhage A. “The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse model”. 2007, Eukaryotic Cell, 12: 2290-2302

54. Mezger M., Kneitz S., Wozniok I., Kurzai O., Einsele H., Loeffler J. “Pro-inflammatory response of human immature dendritic cells is mediated by dectin-1 after exposure to Aspergillus fumigatus germ tubes”. 2008, Journal of Infectious Diseases, 197: 924-931

55. Mezger M., Steffens M., Semmler C., Arlt E.M., Zimmer M., Kristjanson G.I., Wienker T.F., Toliat M.R., Kessler T., Einsele H., Loeffler J. “Investigation of Promotor Variations in DC-SIGN (CD209) and their relevance for human cytomegalovirus reactivation and disease after allogeneic stem cell transplantation. 2007, Clinical Microbiology and Infection, 14: 228-234

56. Gille C., Leiber A., Spring B., Kempf V.A., Loeffler J., Poets C.F., Orlikowsky T.W. “Diminished phagocytosis-induced cell death (PICD) in neonatal monocytes upon infection with Escherichia coli”. 2008, Pediatric Research 63: 33-38

57. Mezger M., Wozniok I., Blockhaus C., Kurzai O., Hebart H., Einsele H., Loeffler J. „Impact of Mycophenolic acid on the functionality of human polymorphnuclear neutrophils and dendritic cells during interaction with Aspergillus fumigatus”. 2008, Antimicrobial Agents and Chemotherapy, 52: 2644-2646

58. Storz K., Loeffler J., Koch, S., Vonthein R., Zouboulis C.C., Fresko I., Yazici H., Kötter I. “IL-6 receptor, IL-8 receptor and TNF-α238 (G/A) polymorphisms are not associated with Behcet`s disease in patients of German or Turkish origin. 2008, Clinical and Experimental Rheumatology 26: 52-55

59. Duval S., Donnelly P., Barnes R., Loeffler J. “PCR-based methods with aspergillosis as a model”. 2008, Journal of Invasive Fungal Infections, 2: 46-51

60. Loeffler J., Haddad Z., Bonin M. Romeike N., Mezger M., Schumacher, U., Kapp M., Gebhardt F., Grigoleit, G.U., Stevanović, S., Einsele, H., Hebart H. “Interaction Analyses of Human Monocytes Co-Cultured with Different Forms of Aspergillus fumigatus“. 2009, Journal of Medical Microbiology, 58: 49-58

61. Mengoli, C., Cruciani M,. Barnes R.A., Loeffler J., Donnelly, P.” A systematic review and meta-analysis of Polymerase chain Reaction for diagnosing invasive aspergillosis”. 2009, Lancet Infectious Diseases, 2: 89-96

62. Klingspor L. & Loeffler J. „Aspergillus PCR formidable challenges and progress”. 2009, Medical Mycology, 47: 241-247

63. Kapp M., Stevanović S., Fick K., Tan S.M., Loeffler J., Opitz A., Tonn T., Stuhler G. Einsele H., Grigoleit G.U. “CD8+ T-cell responses to tumor-associated antigens correlate with superior relapse-free-survival after allogeneic stem cell transplantation”.

2009, Bone Marrow Transplantation, 43: 399-410

64. Hebart H., Klingspor L., Klingebiel T., Loeffler J., Tollemar J., Ljungman P., Wandt H., Schaefer-Eckart K., Dornbusch H.J., Meisner C., Engel C., Stenger N., Mayer T., Ringden O., Einsele H. “A prospective randomized controlled trial comparing PCR-based and empirical treatment with liposomal amphotericin B in patients after allo-SCT”. 2009, Bone Marrow Transplantation, 43: 553-561

65. Ok M., Latgé J.P., Baeuerlein C., Ebel F., Mezger M., Topp M., Kurzai O., Killian D., Kapp M., Grigoleit G.U., Sennefelder H., Arroyo J., Einsele H., Loeffler J. “Immune responses of human immature dendritic cells can be modulated by the recombinant Aspergillus fumigatus antigen Aspf1″. 2009, Clinical and Vaccine Immunology 16: 1485-1492

66. Mezger M., Bonin M., Kessler T., Gebhardt F., Einsele H., Loeffler J. “Toll Like receptor 3 has no critical role during early immune response of human monocyte-derived dendritic cells after infection with the human cytomegalovirus strain TB40E”. 2009, Viral Immunology 22: 343-351

67. Morton C., Loeffler J., de Luca, A., Frost S., Kenny C., Duval S., Romani L., Rogers T. “Dynamics of extracellular release of Aspergillus fumigatus DNA and galactomannan during growth in blood and serum”. 2009, Journal of Medical Microbiology, in press

68. Hornbach A., Heyken A., Schild L., Hube B., Loeffler J., Kurzai O. The glycosylphosphatidylinositol-anchored protease Sap9 modulated the interaction of Candida albicans with human neutrophils”. 2009, Infection and Immunity 77: 5216- 5224

69. Spinnler K., Mezger M., Steffens M., Senefelder H., Kurzai O., Einsele H., Loeffler J. “Role of Glycogen Synthase Kinase 3 (GSK-3) in innate immune response of human immature dendritic cells to Aspergillus fumigatus“. 2010, Medical Mycology, in press

70. White L., Bretagne S., Klingspor L., Melchers W., Mc Culloch E., Schulz B., Finnstrom N., Mengoli C., Barnes R., Donnelly P., Loeffler J. on behalf of the European Aspergillus PCR initiative. “Aspergillus PCR: One step closer to standardization”. 2010, Journal of Clinical Microbiology, in press

71. Kurzwelly D., Knop S., Guenther M., Loeffler J., Korfel A., Thiel E., Hebart H., Simon M., Weller M., Linnebank M., Herrlinger U. “Genetic variants of folate and methionine metabolism and PCNSL incidence in a German patient population”. 2010,

Journal of Neurooncology, in press

72. Loeffler J, Ok M., Morton O., Mezger M., Einsele H. “Genetic Polymorphisms in the Cytokine and Chemokine System: Their Possible Importance in Allogeneic Stem Cell Transplantation”. 2010, Current Topics in Microbiology and Immunology, 341: 83- 96

73. Mezger M., Einsele H., Loeffler J. „Genetic susceptibility to infections with Aspergillus fumigatus“. 2010, Current Reviews in Microbiology, 36: 168-177

74. White L., Perry M., Loeffler J., Melchers W., Klingspor L., Bretagne S., McCulloch E., Cuenca-Estrella M., Finnstrom N., Donnelly P., Barnes R. on behalf of the European Aspergillus PCR Initiative.”Critical stages of extracting DNA from Aspergillus fumigatus in whole blood specimens”. 2010, Journal of Clinical Microbiology, 48: 3753-3756

75. McCormick A., Heesemann, L., Wagener J., Marcos V., Hartl D., Loeffler J., Heesemann J., Ebel F. „NETs formed by human neutrophils inhibit growth of the pathogenic mould Aspergillus fumigatus”. 2010, Microbes and Infection, in press

76. Dannoui E., Schwarz P., Slany M., Loeffler J., Jorde A., Cuenca-Estrella M., Hasuer P., Shrief R., Huerre M., Freiberger T., Gaustrad P., Rodriguez-Tudela J., Bille J., Denning D., Bretagne S., Lortholary O. “Molecular detection and identification of Zygomycetes species from paraffin-embedded tissues in a murine model of disseminated zygomycosis: a collaborative European Society of Clinical Microbiology and Infectious Diseases (ESCMID) fungal infection study group (EFISG) evaluation”. 2010, Journal of Clinical Microbiology 48: 2043-2046

77. Hebart H., Lengerke C., Ljungman P., Paya C., Klingebiel T., Loeffler J., Pfaffenrath S., Lewensohn-Fuchs I., Barkholt L., Tomiuk J., Meisner C., Lunenberg J., Top B., Razonable R., Patel R., Litzow M., Jahn G., Einsele H. “Prospective comparison of PCR-based versus late mRNA-based preemptive antiviral therapy for HCMV infection in patients after allo-SCT”. 2010, Bone Marrow Transplantation, in press

78. McCormick A., Loeffler J., Ebel F. “Aspergillus fumigatus: contours of a human fungal pathogen”. 2010, Cellular Microbiology, 11: 1535-1543

79. Springer J., Loeffler J., Heinz W., Schlossnagel H., Lehmann M., Morton O., Rogers T., Schmitt C., Frosch M., Einsele H., Kurzai O. „Pathogen specific DNA enrichment does not increase sensitivity of PCR for diagnosis of invasive aspergillosis in neutropenic patients”. 2011, Journal of Clinical Microbiology, 49: 1267-1273

80. Flechsig C., Suezer Y., Kapp M., Tan S., Loeffler J., Sutter G., Einsele H., Grigoleit G.U. “Uptake of antigens from modified vaccinia Ankara virus-infected leukocytes enhances the immunostimulatory capacity of dendritic cells”. 2011, Cytotherapy, in press

81. Loeffler J., Barnes R., Donnelly P. “Standardization of Aspergillus PCR diagnosis”. 2011, Bone Marrow Transplantation, in press

82. Morton O., Varga J., Hornbach A., Mezger M., Sennefelder H., Kneitz S., Kurzai O., Krappmann S., Einsele H., Nierman W., Rogers T., Loeffler J. “The temporal dynamics of differential gene expression in Aspergillus fumigatus interacting with human immature dendritic cells in vitro. 2011, PLoS ONE, 6: e16016

83. Beyrich C., Loeffler J., Kobsar A., Speer C., Kneitz S., Eigenthaler M. “Infection of human coronary artery endothelial cells by group B Streptococcus contributes to dysregulation of apoptosis, hemostasis and innate immune responses”. 2011, Mediators of Inflammation, doi:10.1155/2011/971502

84. Staab A., Fleischer M., Loeffler J., Said H., Katzer A., Plathow C., Einsele H., Flentje M., Vordermark D. “Small interfering RNA targeting HIF-1alpha reduces hypoxia-dependent transcription and radiosensitizes hypoxic HT 1080 human fibrosarcoma cells in vitro“. 2011, Strahlentherapie und Onkologie, 187: 252-259

85. Stuehler C., Khanna N., Bozza S., Zelante T., Moretti S., Kruhm M., Lurati S., Conrad B., Worschech E., Stevanovic S., Krappmann S., Einsele H., Latgé J.P., Loeffler J., Romani L., Topp M. “Cross-protective Th1 immunity against Aspergillus fumigatus and Candida albicans“. 2011, Blood, in press

86. Morton O., Clemons K., Springer J., Mueller J., Rogers T., Stevens D., Kurzai O., Einsele H., Loeffler J. “Real-time PCR and quantitative culture for monitoring experimental Aspergillus fumigatus intracranial infection in neutropenic mice”. 2011. Journal of Medical Microbiology, 60: 913-919

87. Bouzani M., Ok M., McCormick A., Ebel F., Kurzai O., Morton O., Einsele H., Loeffler J. “Human NK cells display important antifungal activity against Aspergillus fumigatus, which is directly mediated by Interferon gamma release”. 2011, Journal of Immunology, in press

88. Bauer R., Mezger M., Blockhaus C., Schmitt AL., Kurzai O., Einsele, H., Loeffler J. „40-O-[2-Hydroxyethhly] modulates human dendritic cell function during exposure to Aspergillus fumigatus“. 2011, Journal of Basic Microbiology, in press

89. White L., Mengoli C., Bretagne S., Cuenca Estrella M., Finnstrom N., Klingspor L., Melchers W., McCulloch E., Barnes R., Donnelly P., Loeffler J., on behalf of the European Aspergillus PCR Initiative. „An evaluation of Aspergillus PCR protocols for testing serum specimens”. 2011. Journal of Clinical Microbiology, in press

90. Ok M., Einsele H., Loeffler J. „Genetic susceptibility to Aspergillus fumigatus infections” 2011,. International Journal of Medical Microbiology 301: 445-452

91. Bouzani M., Einsele H., Loeffler J. „Functional analysis is a paramount prerequisite for understanding the in vitro interaction of human Natural Killer cells with Aspergillus fumigatus“. 2012, Journal of Infectious Diseases, in press

92. Springer J., Einsele H., Loeffler J. „Molecular techniques in the diagnosis of deep and systemic mycoses”. 2012, Clinics in Dermatology, in press

93. Donat S., Hasenberg M., Schäfer T., Ohlsen K., Gunzer M., Einsele H., Loeffler J., Beilhack A., Krappmann S. „Surface display of Gaussia princeps luciferase allows sensitive fungal pathogen detection during cutaneous aspergillosis”. 2012, Virulence, in press

94. Springer J., Schloßnagel H., Heinz W., Doedt T., Soeller R., Einsele H., Loeffler J., „A novel method combining plasma with a whole blood fraction shows excellent sensitivity and reproducibility for patients at high risk for invasive aspergillosis”. 2012, Journal of Clinical Microbiology 50: 2585-2591

95. Kapp M., Schargus M., Deuchert T., Springer J., Wendel F., Loeffler J., Grigoleit G., Kurzai O., Heinz W., Einsele H., Stuhler G. „Endophthalmitis as a primary clinical manifestation of fatal fusariosis in an allogeneic stem cell transplant recipient”. 2011, Transplantation Infectious Diseases 13: 374-379

96. Reichard U., Buchheidt D., Lass-Flörl C., Loeffler J., Lugert R., Ruhnke M., Tintelnot K., Weig M., Groß U. „Interlaboratory comparison of PCR-based identification of Candida and Aspergillus DNA in spiked blood samples”. 2012, Mycoses 55: 426-434

97. Morton O., Bouzani M., Loeffler J., Rogers T. “Direct interaction studies between Aspergillus fumigatus and human immune cells; what have we learned about pathogenicity and host immunity. 2012, Frontiers in Microbiology 3:413

98. Maschmeyer G., Heinz W., Hertenstein B., Horst A., Requadt C., Wagner T., Cornely O., Loeffler J., Ruhnke M. „Immediate versus deferred empirical antifungal (IDEA) therapy in high-risk aptients with febrile neutropenia: a randomized, double-blind, placebo-controlled multicentre study”. 2013, European Journal of Clinical Microbiology and Infectious Diseases, 32: 679 – 689

99. Rogers T., Morton O., Springer J., Conneally E., Heinz W., Kenny C., Frost S., Einsele H., Loeffler J. “Combined real-time PCR and galactomannan surveillance improves diagnosis of invasive aspergillosis in high risk patients with haematological malignancies” 2013, British Journal of Haematology, in press

100. Mueller-Loebnitz C., Ostermann H., Franzke A., Loeffler J., Uharek L., Topp M., Einsele H. „Immunological aspects of Candida and Aspergillus systemic fungal infections”. 2013, Interdisciplinary Perspectives on Infectious Diseases, in press

101. Springer J., Morton O., Perry M., Heinz W., Paholcsek M., Alzheimer M., Rogers T., Barnes R., Einsele H., Loeffler J., White L. “Comparison of serum and whole blood specimens for the detection of Aspergillus DNA in high-risk haematological patients: A multicenter evaluation”. 2013, Journal of Clinical Microbiology, in press

102. Tan S.M., Kapp M., Flechsig C., Kapp K., Rachor J., Eyrich M., Loeffler J., Einsele H., Grigoleit U. “Stimulating surface molecules, Th1-polarizing cytokines, proven trafficking-a new protocol for the generation of clinical-grade dendritic cells”. 2013, Cytotherapy, in press

103. Lyon G., Abdul-Ali D., Loeffler J., White L., Wickes B,, Herrera M., Alexander B., Baden L., Clancy C., Denning D., Hong Ngyuen M., Sugrue M., Wheat J., Wingrad J., Donnelly P., Barnes R., Patterson T., Caliendo A. “Development and evaluation of a calibrator material for nucleic acid based assays for diagnosing aspergillosis”. 2013, Journal of Clinical Microbiology 51: 2403-2405

104. Grube M., Loeffler J., Mezger M., Krüger B., Echtenacher B., Hoffmann P., Edinger M., Einsele H., Andreesesn R., Holler E. „TLR5 stop codon polymorphism is associated with invasive aspergillosis after allogeneic stem cell transplantation”. 2013, Medical Mycology, in press

105. Voigt J., Huenniger K., Bouzani M., Jacobsen I., Barz D., Hube B., Löffler J., Kurzai O. “Human NK cells act as phagocytes against Candida albicans and mount an inflammatory response which modulates neutrophil antifungal activity”. 2014, Journal of Infectious Diseases, in press

106. Cunha C., Aversa F., Lacerda J., Busca A., Kurzai O., Grube M., Löffler J., Maertens J., Bell A., Inforzato A., Barbati E., Almeida B., Santos e Sousa P., Barbui A., Potenza L., Caira M., Rodrigues F., Salvatori G., Pagano L., Luppi M., Mantovani A., Velardi A., Romani L., Carvalho A. “Genetic PTX3 deficiency and aspergillosis in stem cell transplantation”. 2014, New England Journal of Medicine 370: 421-432

107. Semmlinger A., Fliesser M., Waaga-Gasser A. Dragan M., Morton O., Einsele H., Loeffler J. „Fever-range temperature modulates activation and function of human dendritic cells stimulated with the pathogenic mould Aspergillus fumigatus“. 2014, Medical Mycology, in press

108. Morton O., Fliesser M., Dittrich M., Mueller T., Bauer R., Kneitz S., Hope W., Rogers T., Einsele H., Loeffler J. „Gene expression profiles of human dendritic cells interacting with Aspergillus fumigatus in a bilayer model of the alveolar epithelial/endothelial interface”. 2014, PLOS One 9e98279

109. Das Gupta M., Fliesser M., Springer J., Breitschopf T., Schlossnagel H., Schmitt A., Kurzai O., Hünniger K., Einsele H., Löffler J. Aspergillus fumigatus induces microRNA-132 in human monocytes and dendritic cells”. 2014, International Journal of Medical Microbiology, in press

110. Lother J., Breitschopf T., Krappmann S., Morton O., Bouzani M., Kurzai O., Gunzer M., Hasenberg M., Einsele H., Loeffler J. „Human dendritic cell subsets display distinct interactions with the pathogenic mould Aspergillus fumigatus“. 2014, International Journal of Medical Microbiology, in press

111. Cunha C., Kurzai O., Löffler J., Aversa F., Romani L., Carvalho A. “Neutrophil responses to Aspergillosis: New roles for old players”. 2014, Mycopathologia 178: 387-393

112. Hünniger K., Bieber K., Martin R., Lehnert T., Figge T., Löffler J., Guo R., Riedemann N., Kurzai O. „A second stimulus required for enhanced antifungal activity of human neutrophils in blood is provided by anaphylatoxin C5a”. 2014, Journal of Immunology, in press

113. Rieber N., Singh A., Carevic M., Öz H., Bouzani M., Amich J., Ost M., ye, Z., Schäfer I., Mezger M., Klimosch S., Weber A., Handgretinger R., Liese J., Engeholm M., Schüle R., Salih H., Marodi L., Speckmann C., Grimbacher B., Ruland J., Brown G., Beilhack A., Loeffler J., Hartl D. “Pathogenic fungi regulate T-cell immunity by including neutrophil myeloid-derived suppressor cells through a dectin-1 / CARD9 and ROS-mediated mechanisms”. 2015, Cell Host and Microbe, in press

114. Loeffler C., Kapp M., Grigoleit U., Mielke S., Loeffler J., Heuschmann P., Malzahn U., Hupp E., Einsele H., Stuhler G. “Control of relapsed or refractory acute myeloid leukemia by clofarabine in preparation for allogeneic stem cell transplantation”. 2015, Leukemia and Lymphoma, in press

115. Leonhardt I., Spielberg S., Weber M., Albrecht-Eckardt D., Bläss M., Claus R., Barz D., Löffler J., Hünniger K., Kurzai O. “The fungal Quorum-Sensing-Molecule Farnesol activates innate immune cells but suppresses cellular adaptive immunity”, 2015, MBio, in press

116. Rambach G., Blum G., Latge J., Fontaine T., Heinekamp T., Hagleitner M., Jeckström H., Weigel G., Würtinger P., Pfaller K., Krappmann S., Löffler J., Lass-Floerl C., Speth C. „Identification of Aspergillus fumigatus surface components that mediate interaction of conidia and hyphae with human platelets”. 2015, Journal of Infectious Diseases, in press

117. Mueller-Leisse J., Brueggemann S., Bouzani M., Schmitt A., Einsele H., Loeffler J. “Polymorphonuclear Neutrophils and Granulocytic Myeloid-Derived Suppressor Cells Inhibit Natural Killer Cell Activity Towards Aspergillus fumigatus“, 2015, Medical Mycology, in press

118. Einsele H., Löffler J., Kapp M., Rasche L., Mielke S., Grigoleit U. „Immunotherapy for viral and fungal infections”. 2015, Bone Marrow Transplantation, in press

119. Löffler C., Löffler J., Kobsar A., Speer S., Eigenthaler M. „Septic versus colonizing Group B Streptococci differentially regulate inflammation and apoptosis in human coronary artery endothelial cells – a pilot study”. 2015, Journal of Pediatrics and Neonatal Care, in press

120. White L., Barnes R., Springer J., Klingspor L., Cuenca-Estrella M., Morton O., Lagrou K., Bretagne S., Melchers W., Mengoli C., Donnelly P., Heinz W., Loeffler J. and the EAPCRI. “The clinical performance of Aspergillus PCR when testing serum and plasma- a study by the European Aspergillus PCR Initiative”, 2015, Journal of Clinical Microbiology, in press

121. Loeffler J., Mengoli C., Springer J., Bretagne S., Cuenca Estrella M., Klingspor L., Lagrou K., Melchers W., Morton O., Barnes R., Donnelly P., White L., on behalf of the European Aspergillus PCR Initiative. “Analytical comparison of in vitro spiked human serum and plasma for the PCR-based detection of Aspergillus fumigatus DNA – a study by the European Aspergillus PCR Initiative”, 2015, Journal of Clinical Microbiology, in press

122. White L., Wingard J., Bretagne S., Loeffler J., Patterson T., Slavin M., Barnes R., Pappas P., Donnelly P. “Aspergillus PCR: a systematic review of evidence for clinical use in comparison with antigen testing”, 2015, Clinical Infectious Diseases, in press  

123. Paholcsek M., Fidler G., Kónya J., Rejto L., Méhes G., Bukta E., Loeffler J., Biró S. “Combining standard clinical methods with PCR showed improved diagnosis of invasive pulmonary aspergillosis in patients with hematological malignancies and prolonged neutropenia”, 2015, BMC Infectious Diseases, in press

124. Beitzen-Heineke A., Bouzani M., Schmitt A., Kurzai O., Huenniger K., Einsele H., Loeffler J. „Invariant Natural Killer T cells possess immune-modulating functions during Aspergillus fumigatus infection”, 2015 Medical Mycology, in press

125. Fliesser M., Morton O., Bonin M., Ebel F., Hünniger K., Kurzai O., Einsele H., Löffler J. „Hypoxia-inducible factor 1α modulates metabolic activity and cytokine release in anti-Aspergillus fumigatus immune responses initiated by human dendritic cells”, 2015, International Journal of Medical Microbiology, in press

126. Cruciani M., Mengoli C., Loeffler J., Donnelly P., Barnes R., Jones B., Klingspor L., Morton O., Maertens J. “Polymerase chain reaction blood tests for the diagnosis of invasive aspergillosis in immunocompromised people”, 2015, Cochrane Database of Systematic Reviews, Issue 9. Art. No.: CD009551

127. Springer J., Lackner M., Nachbaur D., Girschikofsky M., Risslegger B., Mutschlechner W., Fritz J., Heinz W., Einsele H., Ullmann A., Loeffler J., Lass-Florl C., “Prospective multicenter PCR-based Aspergillus DNA screening in high risk patients with and without primary antifungal mold prophylaxis”, 2015, Clinical Microbiology and Infection, in press

128. Irmer H., Tarazona S., Sasse C., Olbermann P., Loeffler J., Krappmann S., Conesa A., Braus G. „RNAseq analysis of Aspergillus fumigatus in blood reveals a just wait and see resting stage behavior”, 2015, BMC Genomics, 16: 640-665

129. Lupianez C., Canet L., Carvalho A., Alcazar-Fuoli C., Springer J., Lackner M., Segura-Catena J., Comino A., Olmedo C., Rios R., Fernández-Montoya A., Cuenca-Estrella M., Solano C., Lopez-Nevot M., Cunha C., Oliveira-Coelho A., Villaescusa C., Fianchi L., Aguado J., Pagano L., Lopez-Fernandez L., Potenza L., Luppi M., Lass-Flörl C., Löffler J., Einsele H., Vázquez L., Study Group PCRAGA, Jurado M., Sainz J. “Polymorphisms in host immunity modulating genes and risk of invasive aspergillosis: Results from the aspBIOmics consortium”, 2015, Infection and Immunity, in press

130. Springer J., White L., Hamilton S., Michel D., Barnes R., Einsele H., Löffler J. “A comparison of the performance of Aspergillus PCR when testing a range of blood based samples in accordance with international methodological recommendations”, 2016, Journal of Clinical Microbiology, in press

131. Springer J., Goldenberger D., Schmidt F., Weisser M., Wehrle-Wieland E., Einsele H., Frei R., Loeffler J. “Development and application of two independent real-time PCR assays to detect clinically relevant Mucorales species”, 2016, Journal of Medical Microbiology, in press

132. White L., Wiederhold N., Loeffler J., Najvar L., Melchers W., Herrera M., Bretagne S., Wickes B., Kirkpatrick W., Barnes R., Donnelly P., Patterson T. “A comparison of the non-culture blood-based tests for diagnosing invasive aspergillosis in an animal model”, 2016, Journal of Clinical Microbiology, in press

133. Dix A., Czakai K., Springer J., Fliesser M., Bonin M., Guthke R., Schmitt A., Einsele H., Linde J., Löffler J. “Genome-wide Expression Profiling Reveals S100B as Biomarker for Invasive Aspergillosis”, 2016, Frontiers in Microbiology, in press

134. Fliesser M., Wallstein M., Kurzai O., Einsele H., Loeffler J. “Hypoxia attenuates anti-Aspergillus fumigatus immune responses initiated by human dendritic cells”, 2016, Mycoses, in press

135. Teutschbein J., Simon S., Lother J., Springer J., Hortschansky P., Morton O., Löffler J., Einsele H., Conneally E., Rogers T., Guthke R., Brakhage A., Kniemeyer O. “Proteomic profiling of serological responses to Aspergillus fumigatus antigens in patients with invasive aspergillosis”, 2016, Journal of Proteome Research, in press

136. Hellwig D., Voigt J., Bouzani M., Löffler J., Albrecht-Eckardt D., Weber M., Brunke S., Martin R., Kurzai O., Hünniger K. “Candida albicans induces Metabolic Reprogramming in human NK cells and responds to Perforin with a Zinc Depletion Response”, 2016, Frontiers in Microbiology, in press

137. Czakai K, Leonhardt I, Dix A, Bonin M, Linde J, Einsele H, Kurzai O, Loeffler J. “Krüppel-like Factor 4 modulates interleukin-6 release in human dendritic cells after in vitro stimulation with Aspergillus fumigatus and Candida albicans“. 2016. Nature Scientific Reports.6: 27990. doi: 10.1038/srep27990.

138. Morton O. White L., Barnes R., Klingspor L., Cuenca-Estrella M., Lagrou K. Bretagne S., Melchers W., Mengoli C., Caliendo A., Cogliati M., Debets Y., Gorton R., Hagen F., Halliday C., Hamal P., Harvey-Wood K., Jaton K., Johnson G., Kidd S., Lengerova M., Lass-Flörl C., Linton C., Millon L., Morrissey O., Paholcsek M., Talento A., Ruhnke M., Willinger B., Donnelly P., Loeffler J. “Determining the analytical specificity of PCR-based assays for the diagnosis of IA: what is Aspergillus?”, 2016, Medical Mycology, in press

139. Lupiañez C., Villaescusa M., Carvalho A., Springer J., Lackner M., Sánchez-Maldonado J., Canet L., Cunha C., Segura-Catena J., Alcazar-Fuoli L., Solano C., Fianchi L., Pagano L., Potenza L., Aguado J., Luppi M., Cuenca-Estrella M., Lass-Flörl C., Einsele H., Vázquez L., PCRAGA Study Group, Ríos-Tamayo R., Loeffler J., Jurado M., Sainz J. “Common genetic polymorphisms within NFκB-related genes and the risk of developing invasive aspergillosis”, 2016, Frontiers in Microbiology, in press

140. Hefter M., Lother J., Weiß E., Schmitt A:, Fliesser M., Einsele H., Loeffler J. „Human primary myeloid dendritic cells interact with the opportunistic fungal pathogen Aspergillus fumigatus via the C type lectin receptor Dectin-1″, 2016, Medical Mycology, in press

141. Loeffler J., Hafner J., Mengoli C., Wirth C., Heussel C., LöfflerC., White L., Ullmann A., Michel M., Wiegering V., Wölfl M., Schlegel P., Einsele H., Springer J., Eyrich, M. “Prospective biomarker screening for the diagnosis of invasive aspergillosis in high-risk paediatric patients”, 2016, Journal of Clinical Microbiology, in press

142. Fuji S., Loeffler J., Savani B., Einsele H., Kapp M. „Hyperglycemia as a possible risk factor for mold infections – the potential preventative role of intensified glucose control in allogeneic hematopoietic stem cell transplantation”, 2016, Bone Marrow Transplantation, in press

143. Czakai K., Dittrich M., Kaltdorf M., Müller M., Krappmann S., Schedler A., Bonin M., Dühring S., Schuster S., Speth C., Rambach G., Einsele H., Dandekar T., Löffler J. „Influence of Platelet-rich Plasma on the immune response of human monocyte-derived dendritic cells and macrophages stimulated with Aspergillus fumigatus“, 2016, International Journal of Medical Microbiology, in press

144. Dix A., Czakai K., Leonhardt I., Schäferhoff K., Bonin M., Guthke R., Einsele H., Kurzai O., Löffler J.*, Linde J. “Specific and novel microRNAs are regulated as response to fungal infection in human dendritic cells”, 2017, Frontiers in Microbiology, in press

145. Cunha C., Duarte-Oliveira C., Gonçalves S., Leite L., Lagrou K., Marques A, Lupiañez C., Barbosa A., Gaifem J., Mesquita I., Vaz C., Branca R., Campilho F., Freitas F., Ligeiro D., Lass-Flörl C., Löffler J., Jurado M., Saraiva M., Kurzai O., Rodrigues F., Castro A., Silvestre R., Sainz J., Maertens J., Torrado E., Jacobsen I., Lacerda J., Campos A, Carvalho A. “IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity”, 2017, Journal of Allergy and Clinical Immunology, in press

146. Talento A., Dunne K., Joyce, E., Palmer E., Johnson E., White L., Springer J. Loeffler J. Ryan T., Collins D., Rogers T. “A prospective study of fungal biomarkers to improve management of invasive fungal diseases in a mixed specialty critical care unit”, 2017, Journal of Critical Care, in press

147. Wurster S., Thielen V., Weis P., Walther P., Elias J., Waaga-Gasser A., Dragan M., Dandekar T., Einsele H., Löffler J., Ullmann A. „Mucorales spores 1 induce a proinflammatory cytokine response in human mononuclear phagocytes and harbor no rodlet hydrophobins”, 2017, Virulence, in press

148. Barnes R., White L. Morton O., Rogers T., Cruciani M., Loeffler J., Donnelly P. “Aspergillus PCR in Practice: Clinical Considerations and Technical Tips”, 2017, Medical Mycology, in press

149. Decker C., Wurster S., Lazariotou M., Hellmann A., Einsele H., Ullmann A., Löffler J. „Analysis of the in-vitro activity of human neutrophils against Aspergillus fumigatus in presence of antifungal and immuno-suppressive agents”, 2017, Medical Mycology, in press

150. Ziegler S., Weiss E., Schmitt A., Schlegel J., Burgert A., Terpitz U., Sauer M., Moretta L., Sivori S., Leonhardt I., Kurzai O., Einsele H., Loeffler J. „CD56 Is a Pathogen Recognition Receptor on Human Natural Killer Cells”, 2017, Scientific Reports, in press

151. Saraiva J., Oswald M., Biering A., Röll D., Assmann C., Klassert T., Blaess M., Czakai K., Claus R., Löffler J., Slevogt H., König R., „Fungal biomarker discovery by integration of classifiers“, 2017, BMC Genomics 18: 601 doi: 10.1186

152. Springer J., White L., Kessel J., Wieters I., Teschner D., Korczynski D., Liebregts T., Cornely O., Schwartz S., Elgeti T., Meintker L., Krause S., Posso R., Heinz1 W., Fuhrmann S., Vehreschild J., Einsele H., Rickerts V., Loeffler J. „A Multi-Centre Comparison of Aspergillus and Mucorales PCR Testing of different BAL Fractions”, 2017, Journal of Clinical Microbiology, in press

153. Hellmann A., Lother J., Wurster S., Lutz M., Schmitt1 A., Morton O., Eyrich M., Czakai K., Einsele H., Loeffler J. „Human and murine innate immune cell populations display common and distinct response patterns during their in vitro interaction with the pathogenic mould Aspergillus fumigatus”, 2017, Frontiers in Immunology, in press

154. Ullmann A., Aguado J., Arikan S., Denning D Groll A., Lagrou K., Lass-Florl C., Lewis R., Muñoz P., Verweij P., Warris A. Akova M., Arendrup M., Barnes R., Blot S., Bouza E., Brüggemann R., Buchheidt D. Cadranel J., Chakrabarti A., Cuenca-Estrella M., Dimopoulos G., Gangneux J., Garbino J., Heinz W., Herbrecht R., Kibbler C., Klimko N. Kullberg B., Lange C., Lehrnbecher T., Loeffler J., Lortholary O., Maertens J., Cornely O. “Diagnosis and Management of Aspergillus Diseases: Executive Summary of the 2017 ESCMID-ECMM-ERS Guideline”, 2018, Clinical Microbiology and Infection, in press

155. Lauruschkat C., Wurster S. Page L., Lazariotou M., Dragan M., Weis P., Ullmann A., Einsele H., Löffler J., “Susceptibility of A. fumigatus specific T-cell assays to pre-analytic blood storage and PBMC cryopreservation greatly depends on readout platform and analytes”, 2018, Mycoses, in press

156. Springer J., McCormick Smith I., Hartmann S., Winkelmann R., Wilmes D., Cornely O., Kessel J., Löffler J., Rickerts V., „Identification of Aspergillus and Mucorales in Formalin-Fixed, Paraffin-Embedded Tissue Samples: Comparison of Specific and Broadrange Fungal qPCR Assays”, 2018, Medical Mycology, in press

157. White, L., Barnes, R., Gorton R., Cruciani M., Loeffler J., “COMMENT ON: T2Candida MR as a predictor of outcome in patients with suspected invasive candidiasis starting empirical antifungal treatment: a prospective pilot study”, 2018, Journal of Antimicrobial Chemotherapy, in press

158. Voltersen V., Blango M., Herrmann S., Schmidt F., Heinekamp T., Strassburger M., Krüger T., Bacher P., Lother J., Weiss E., Hünniger K., Liui H., Hortschansky P., Scheffold A., Löffler J., Krappmann S., Nietzschek S., Kurzai O., Einsele H., Kniemeyer O., Filler S., Reichard U., Brakhage A., „Proteome analysis reveals the conidial surface protein CcpA essential for virulence of the pathogenic fungus Aspergillus fumigatus”, 2018, mBIO, in press

159. Weiss E., Ziegler S., Fliesser M., Schmitt A., Huenniger K., Kurzai O., Morton O., Einsele H., Loeffler J., „First insights in NK – DC cross-talk and the importance of soluble factors during infection with Aspergillus fumigatus”, 2018, Frontiers in Cellular and Infection Microbiology, in press

160. Morton O., Wurster S., Fliesser M., Ebel F., Page L., Hünniger K., Kurzai O., Schmitt A., Michel D., Springer J., Einsele H., Loeffler J., „Validation of a simplified in vitro Transwell® model of the alveolar surface to assess host immunity induced by different morphotypes of Aspergillus fumigatus”, 2018, International Journal of Medical Microbiology, in press

161. Page L., Weis P., Mueller T., Dittrich M., Lazariotou M., Dragan M., Waaga-Gasser A., Helm J., Dandekar T., Loeffler J., Ullmann A., Einsele H., „Evaluation of Aspergillus and Mucorales specific T-cells and PBMC cytokine signatures as biomarkers of environmental mold exposure”, 2018, International Journal of Medical Microbiology, in press

162. Hoenigl M., Oraschd T., Faserle K., Prattes J., Loeffler J., Springer J., Gsallerd, F., Reischies F., Duettmann W., Raggam R., Lindner H., Haas H., “Triacetylfusarinine C: a urine biomarker for diagnosis of invasive aspergillosis”, 2018, Journal of Infection, in press

163. Caetano L., Faria T., Springer J., Loeffler J., Viegas C., “Antifungal drug-resistance in Mucorales in different indoor environments”, 2018, Mycology: An International Journal on Fungal Biology, in press

164. Loeffler J., Ebel, F. “Size matters – how the immune system deals with fungal hyphae, 2018, Microbes and Infection, in press

165. Belic S., Page L., Lazariotou M., Waaga-Gasser A., Dragan M., Springer J., Loeffler J., Morton O., Einsele H., Ullmann A., Wurster S., Comparative analysis of inflammatory cytokine release and alveolar epithelial barrier invasion in a Transwell® bilayer model of mucormycosis, 2018, Frontiers in Microbiology, in press

166. Lauruschkat C., Einsele H., Loeffler J., Immunomodulation as a Therapy for Aspergillus Infection: Current Status and Future Perspectives, 2018, Journal of Fungi, in press

167. Marischen L., Englert A., Schmitt A. Einsele H., Loeffler J., „Human NK cells adapt their immune response towards increasing multiplicities of infection of Aspergillus fumigatus”, 2018, BMC Immunology, in press