Publikationsverzeichnis
Prof. Dr. rer. nat. Jürgen Löffler
Wissenschftliche Orginalarbeiten
1. Einsele H., Ehninger G., Hebart H., Wittkowski K.M., Schuler U., Jahn G., Mackes P., Herter M., Klingebiel T., Löffler J., Wagner S., Müller C.A. Polymerase chain reaction reduces the incidence of cytomegalovirus disease and the duration and side effects of antiviral therapy after bone marrow transplantation. 1995, Blood, 86: 2815-2820
2. Löffler J., Schumacher U., Hebart H., Reitze H., Einsele H. Extraction of fungal DNA from cultures and blood using the QIAamp Tissue Kit. 1996, Qiagen News, 4/96: 16-17,
3. Hebart H., Müller C.A., Löffler J., Jahn G., Einsele H. Monitoring of CMV infection: a comparison of PCR from whole blood, plasma-PCR, pp65 antigenemia and virus culture in patients after bone marrow transplantation. 1996, Bone Marrow Transplantation, 17: 861-868
4. Kelly S.L., Lamb D.C., Kelly D.E., Loeffler J., Einsele H. Resistance to fluconazole and amphotericin B in Candida albicans from AIDS patients. 1996, Letter to Lancet, 348: 1523-1524,
5. Löffler J., Kelly S.L., Hebart H., Schumacher U., Lass-Floerl C., Einsele H. Molecular analysis of CYP51 from fluconazole-resistant Candida albicans strains. 1997, FEMS Microbiology Letters, 151: 263-268
6. Löffler J., Hebart H., Schumacher U., Reitze H., Einsele H. Comparison of different methods for fungal DNA extraction from cultures and blood. 1997, Journal of Clinical Microbiology, 35: 3311-3312
7. Kelly S.L., Lamb D.C., Kelly D.E., Manning N.J., Loeffler J., Hebart H., Schumacher U., Einsele H. Resistance to fluconazole and cross-resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol Δ5,6 desaturation. 1997, FEBS Letters, 400: 80-82
8. Hebart H., Schröder A., Löffler J., Klingebiel T., Martin H., Wassmann B., Gerneth F., Rabenau H., Jahn G., Kanz L., Müller C.A., Einsele H. Cytomegalovirus monitoring by polymerase chain reaction of whole blood samples from patients undergoing autologous bone marrow or peripheral blood progenitor cell transplantation. 1997, Journal of Infectious Diseases 175: 1490-1493
9. Einsele H., Hebart H., Roller G., Löffler J., Rothenhöfer I., Müller C.A., Bowden R.A., van Burik J.A., Engelhard D., Kanz L., Schumacher U. Detection and identification of fungal pathogens in blood by using molecular probes. 1997, Journal of Clinical Microbiology, 35: 1353-1360
10. Loeffler J., Hebart H., Sepe S., Schumacher U., Klingebiel T., Einsele H. Detection of PCR-amplified fungal DNA by using a PCR-ELISA system. 1998, Medical Mycology, 36: 275-279
11. Hebart H., Löffler J., Jahn G., Einsele H. Reply to Kawasaki et al., „Cytomegalovirus monitoring by culture of urine and throat swabs from Japanese children undergoing autologous bone marrow or peripheral blood progenitor or allogeneic bone marrow transplantation”, Reply – JID A 970873. 1998, Journal of Infectious Diseases, 177: 519-520
12. Hebart H., Gamer D., Loeffler J., Müller C.A., Sinzger C., Jahn G., Bader P., Klingebiel T., Kanz L., Einsele H. Evaluation of Murex CMV DNA hybrid capture assay for detection and quantitation of cytomegalovirus infection in patients following allogeneic stem cell transplantation. 1998, Journal of Clinical Microbiology, 36: 1333-1337
13. Einsele H., Quabeck K., Müller K.D., Hebart H., Rothenhöfer I., Löffler J., Schaefer U.W. Prediction of invasive pulmonary aspergillosis from colonization of the lower respiratory tract before marrow transplantation. 1998, Letter to Lancet, 352: 1443
14. Loeffler J., Hebart H., Bialek R., Hagmeyer L., Schmidt D., Serey F.P., Hartmann M., Eucker J., Einsele H. Contaminations occuring in fungal PCR assays. 1999, Journal of Clinical Microbiology, 37: 1200-1202
15. Löffler J., Einsele H., Hebart H., Schumacher U., Hrastnik C., Daum G. Phospholipid and sterol analysis of plasma membranes of azole-resistant Candida albicans strains. 1999, FEMS Microbiology Letters, 185: 59-63
16. Loeffler J., Hagmeyer H., Hebart H., Henke H., Schumacher U., Einsele H. Rapid detection of point mutations by fluorescence resonance energy transfer and probe melting curves in Candida species. 2000, Clinical Chemistry, 46: 631-635
17. Kelly S.L., Lamb D.C., Loeffler J., Einsele H., Kelly D.E. The G464S amino acid substitution in Candida albicans sterol 14α-demethylase causes fluconazole resistance in the clinic through reduced affinity. 1999, Biochemical and Biophysical Research Communications, 262: 174-179
18. Loeffler J., Hagmeyer H., Hebart H., Henke H., Schumacher U., Einsele H. Rapid detection of point mutations by fluorescence resonance energy transfer and probe melting curves in Candida species. 2000, Clinical Chemistry, 46: 631-635,
19. Einsele H., Hebart H., Kauffmann-Schneider C., Sinzger C., Jahn G., Bader P., Klingebiel T., Dietz K., Löffler J., Bokemeyer C., Müller C., Kanz L. Risk factors for treatment failures in patients receiving PCR-based preemptive therapy for CMV infection. 2000, Bone Marrow Transplantation, 25: 757-763
20. Loeffler J., Henke H., Hebart H., Schmidt D., Hagmeyer H., Schumacher U., Einsele H. Quantification of fungal DNA by using fluorescence resonance energy transfer and the LightCycler system. 2000, Journal of Clinical Microbiolgy, 38: 586-590
21. Loeffler J., Hebart H., Brauchle U., Schumacher U., Einsele H. Comparison between plasma and whole blood specimens for detection of Aspergillus DNA by PCR. 2000, Journal of Clinical Microbiology, 38: 3830-3833
22. Loeffler J., Hebart H., Magga S., Schmidt D., Klingspor L., Tollemar J., Schumacher U., Einsele H. Identification of rare Candida species and other yeasts by polymerase chain reaction and slot blot hybridization. 2000, Diagnostic Microbiology and Infectious Diseases, 38: 207-212
23. Hebart H., Löffler J., Reitze H., Engel A., Schumacher U., Klingebiel T., Bader P., Böhme A., Martin H., Bunjes D., Kern W.V., Kanz L., Einsele H. Prospective screening by a panfungal polymerase chain reaction assay in patients at risk for fungal infections: implications for the management of febrile neutropenia. 2000, British Journal of Haematology, 111: 635-640
24. Hebart H., Löffler J., Meisner C., Serey F., Schmidt D., Böhme A., Martin H., Engel A., Bunjes D., Kern W.V., Schumacher U., Kanz L., Einsele H. Early detection of Aspergillus infection after allogeneic stem cell transplantation by polymerase chain reaction screening. 2000, Journal of Infectious Diseases, 181: 1713-1719
25. Hebart H., Loeffler J., Kanz L., Einsele H. Molecular methods in the diagnosis of infections in the immunocompromised host. 2000, Current Opinion in Infectious Diseases, 13: 355-359
26. Loeffler J., Hebart H., Cox P., Flues N., Schumacher U., Einsele H. Nucleic acid sequence-based amplification of Aspergillus RNA in blood samples. 2001, Journal of Clinical Microbiology, 39: 1626-1629
27. Hebart H., Brugger W., Grigoleit U., Gscheidle B., Loeffler J., Schäfer H.J.., Kanz L., Einsele H. Risk for Cytomegalovirus disease in patients receiving polymerase chain reaction-based preemptive antiviral therapy after allogeneic stem cell transplantation depends on transplantation modality. 2001, Correspondence to Blood, 97: 2183-2185
28. Hebart H., Wuchter P., Loeffler J., Gscheidle B., Hamprecht K., Sinzger C., Jahn G., Dietz K., Kanz L., Einsele H. Evaluation of the Murex CMV DNA Hybrid Capture assay (version 2.0) for early diagnosis of cytomegalovirus infection in recipients of an allogeneic stem cell transplant. 2001, Bone Marrow Transplantation, 28: 213-218,
29. Rickerts V., Loeffler J., Böhme A., Einsele H., Just-Nübling G. Diagnosis of disseminated zygomycosis using a polymerase chain reaction assay. 2001, European Journal of Clinical Microbiology and Infectious Diseases, 20: 744-745
30. Loeffler J., Kloepfer K., Hebart H., Najvar L., Graybill J.R., Kirkpatrick W.R., Patterson T.F., Dietz K., Bialek R., Einsele H. Polymerase chain reaction detection of Aspergillus-DNA in experimental models of invasive Aspergillosis. 2002, Journal of Infectious Diseases, 185: 1203-1206
31. Loeffler J., Schmidt K., Hebart H., Schumacher U., Einsele H. Automated extraction of genomic DNA from medically important yeast species and filamentous fungi by using the MagNAPure LC system. 2002, Journal of Clinical Microbiology, 40: 2240-2243
32. Loeffler J., Bauer R., Hebart H., Douek D.C., Rauser G., Bader P., Einsele H. Quantification of T-cell receptor excision circle DNA using fluorescence resonance energy transfer and the LightCycler system. 2002, Journal of Immunological Methods, 271: 167-175
33. Hebart H., Daginik S., Stevanovic S., Grigoleit U., Dobler A., Baur M., Rauser G., Sinzger C., Jahn G., Loeffler J., Kanz L., Rammensee H.G., Einsele H. Sensitive detection of human cytomegalovirus peptide-specific cytotoxic T-lymphocyte responses by interferon-gamma-enzyme-linked immunospot assay and flow cytometry in healthy individuals and in patients after allogeneic stem cell transplantation. 2002, Blood, 99: 3830-3837
34. Einsele H., Roosnek E., Rufer N., Sinzger C., Riegler S., Löffler J., Grigoleit U., Moris A., Rammensee H.G., Kanz L., Kleihauer A., Frank F., Jahn G., Hebart H. Infusion of Cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy. 2002, Blood, 99: 3916-3922,
35. Hebart H., Bollinger C., Fisch, P., Sarfati J., Meisner C., Baur M., Loeffler J., Monod M., Latge JP., Einsele H. Analysis of T-cell responses to Aspergillus fumigatus antigens in healthy individuals and patients with hematological malignancies. 2002, Blood, 100: 4521-4528
36. Hebart H., Rudolph T., Loeffler J., Middeldorp J., Ljubicic T., Jahn G., Einsele H. Evaluation of the Nuclisens CMV pp67 assay for detection and monitoring of human cytomegalovirus infection after allogeneic stem cell transplantation. 2002, Bone Marrow Transplantation, 30: 181-187
37. Von Müller L., Hampl W., Hinz J., Meisel H., Reip A., Engelmann E., Heilbronn R., Gärtner B., Krämer O., Einsele H., Hebart H., Ljubicic T., Löffler J., Mertens T. High variability between results of different in house tests for cytomegalovirus monitoring and a standardized quantitative plasma CMV PCR assay. 2002, Journal of Clinical Microbiology, 40: 2285-2287
38. Loeffler J., Dorn C., Hebart H., Cox P., Magga S., Einsele H. Development and evaluation of the Nuclisens Basic Kit NASBA for the detection of RNA from Candida species frequently resistant to antifungal drugs. 2003, Diagnostic Microbiology and Infectious Diseases, 45: 217-220
39. Loeffler J., Swatoch P., Akhawi-Araghi D., Hebart H., Einsele H. Automated RNA extraction by MagNAPure followed by rapid quantification of cytokine and chemokine gene expression with use of fluorescence resonance energy transfer. 2003, Clinical Chemistry, 49: 955-958
40. Kuci S., Wessels JT., Bühring HJ., Schilbach K., Schumm M., Seitz G., Löffler J., Bader P., Schlegel PG., Niethammer D., Handgretinger R. Identification of a novel class of human adherent CD34– stem cells that give rise to SCID-repopulating cells. 2003, Blood, 101: 869-876
41. Hebart H., Rauser G., Stevenovic S., Haenle C., Nussbaum A.K., Meisner C., Bissinger A.L., Tenzer S., Jahn G., Loeffler J., Rammensee H.G., Schild H., Einsele H. A CTL epitope from human cytomegalovirus IE1 defined by combining prediction
of HLA binding and proteasomal processing is the target of dominant immune responses in patients after allogeneic stem cell transplantation. 2003, Experimental Hematology 31: 966-973
42. Waidmann M., Bechtold O., Frick J.S., Lehr H.A., Schubert S., Dobrindt U., Löffler J., Bohn E., Autenrieth I.B. Bacteroides vulgatus protects against Escherichia coli induced colitis in gnotobiotic interleukin-2 deficient mice. 2003, Gastroenterology, 125: 162-177
43. Braedel S., Radsak M., Einsele H., Latgé J., Michan A., Loeffler J., Haddad Z., Grigoleit U., Schild H., Hebart H. “Aspergillus fumigatus antigens activate innate immune cells via toll-like receptors 2 and 4.”. 2004, British Journal of Haematology 125: 392-399
44. Bissinger A.L., Einsele H., Hamprecht K., Schumacher U., Kandolf R., Loeffler J., Aepinus C., Bock, T., Jahn G., Hebart H. “Infectious pulmonary complications after stem cell transplantation or chemotherapy: Diagnostic yield of bronchoalveolar lavage”. 2005, Diagnostic Microbiology and Infectious Diseases 52: 277 – 280
45. Kötter I., Daikeler T., Einsele H., Koch S., Lochmann L., Kanz L., Loeffler J. “Relapse of autoimmune diseases after autologous T cell depleted stem cell transplantation may be triggered by T cells recently emigrated from the thymus”. 2005, Annals of the Rheumatic Diseases 64: 1787 – 1789
46. Loeffler J., Steffens M., Arlt E.M., Toliat M.R., Mezger M., Suk A., Wienker T.F., Hebart H., Nurnberg P., Boeckh M., Ljungman P., Trenschel R., Einsele H. “Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10 and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation”. 2006, Journal of Clinical Microbiology 44: 1847 – 1850
47. Gille C., Spring B., Tewes L., Loeffler J., Dannecker G.E., Hoffmann M.K., Eichner M., Poets C.F., Orlikowsky T.W. “Diminished response to Interleukin-10 and reduced antibody-dependent cellular cytotoxicity of cord blood monocyte-derived macrophages”. 2006, Pediatric Research 60: 153 – 158
48. Lengerke C., Ljubicic T., Meisner C., Loeffler J., Sinzger C., Einsele H., Hebart H. „Evaluation of the COBAS Amplicor HCMV Monitor for early detection and monitoring of human cytomegalovirus infection after allogeneic stem cell transplantation”. 2006, Bone Marrow Transplantation 38: 53-60
49. Staab A., Loeffler, J., Said H.M., Katzer A., Beyer M., Polat B., Einsele H., Flentje M., Vordermark D. “Modulation of glucose metabolism inhibits hypoxic accumulation of hypoxia-inducible fator-1α (HIF-1α)”. 2007, Strahlentherapie und Onkologie 183: 366-373
50. Staab A., Loeffler J., Said H.M., Diehlmann D., Katzer A., Beyer M., Fleischer M., Schwab F., Baier K., Einsele H., Flentje M., Vordermark D. “Effects of HIF-1 inhibition by chemotin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells”. 2007, BMC Cancer 7: 213
51. Mezger M., Steffens M., Beyer M., Manger C., Eberle J., Toliat M.R., Wienker T.F., Ljungman P., Hebart H., Dornbusch H.J., Einsele H., Loeffler J. “Polymorphisms in the chemokine (C-X-C motif) ligand 10 are associated with invasive aspergillosis after allogeneic stem cell transplantation and influence CXCL10 expression in monocyte-derived dendritic cells”. 2008, Blood, 111: 534-536
52. Wozniok I., Bach A., Schmitt C., Frosch M., Einsele H., Hube B., Loeffler J., Kurzai O. “Induktion of ERK-kinase signaling triggers morphotype-specific killing of Candida albicans filaments by human neutrophils”. 2007, Cellular Microbiology, 10: 807-820
53. Lessing F., Kniemeyer O., Wozniok I., Loeffler J., Kurzai O., Haertl A., Brakhage A. “The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse model”. 2007, Eukaryotic Cell, 12: 2290-2302
54. Mezger M., Kneitz S., Wozniok I., Kurzai O., Einsele H., Loeffler J. “Pro-inflammatory response of human immature dendritic cells is mediated by dectin-1 after exposure to Aspergillus fumigatus germ tubes”. 2008, Journal of Infectious Diseases, 197: 924-931
55. Mezger M., Steffens M., Semmler C., Arlt E.M., Zimmer M., Kristjanson G.I., Wienker T.F., Toliat M.R., Kessler T., Einsele H., Loeffler J. “Investigation of Promotor Variations in DC-SIGN (CD209) and their relevance for human cytomegalovirus reactivation and disease after allogeneic stem cell transplantation. 2007, Clinical Microbiology and Infection, 14: 228-234
56. Gille C., Leiber A., Spring B., Kempf V.A., Loeffler J., Poets C.F., Orlikowsky T.W. “Diminished phagocytosis-induced cell death (PICD) in neonatal monocytes upon infection with Escherichia coli”. 2008, Pediatric Research 63: 33-38
57. Mezger M., Wozniok I., Blockhaus C., Kurzai O., Hebart H., Einsele H., Loeffler J. „Impact of Mycophenolic acid on the functionality of human polymorphnuclear neutrophils and dendritic cells during interaction with Aspergillus fumigatus”. 2008, Antimicrobial Agents and Chemotherapy, 52: 2644-2646
58. Storz K., Loeffler J., Koch, S., Vonthein R., Zouboulis C.C., Fresko I., Yazici H., Kötter I. “IL-6 receptor, IL-8 receptor and TNF-α238 (G/A) polymorphisms are not associated with Behcet`s disease in patients of German or Turkish origin. 2008, Clinical and Experimental Rheumatology 26: 52-55
59. Duval S., Donnelly P., Barnes R., Loeffler J. “PCR-based methods with aspergillosis as a model”. 2008, Journal of Invasive Fungal Infections, 2: 46-51
60. Loeffler J., Haddad Z., Bonin M. Romeike N., Mezger M., Schumacher, U., Kapp M., Gebhardt F., Grigoleit, G.U., Stevanović, S., Einsele, H., Hebart H. “Interaction Analyses of Human Monocytes Co-Cultured with Different Forms of Aspergillus fumigatus“. 2009, Journal of Medical Microbiology, 58: 49-58
61. Mengoli, C., Cruciani M,. Barnes R.A., Loeffler J., Donnelly, P.” A systematic review and meta-analysis of Polymerase chain Reaction for diagnosing invasive aspergillosis”. 2009, Lancet Infectious Diseases, 2: 89-96
62. Klingspor L. & Loeffler J. „Aspergillus PCR formidable challenges and progress”. 2009, Medical Mycology, 47: 241-247
63. Kapp M., Stevanović S., Fick K., Tan S.M., Loeffler J., Opitz A., Tonn T., Stuhler G. Einsele H., Grigoleit G.U. “CD8+ T-cell responses to tumor-associated antigens correlate with superior relapse-free-survival after allogeneic stem cell transplantation”.
2009, Bone Marrow Transplantation, 43: 399-410
64. Hebart H., Klingspor L., Klingebiel T., Loeffler J., Tollemar J., Ljungman P., Wandt H., Schaefer-Eckart K., Dornbusch H.J., Meisner C., Engel C., Stenger N., Mayer T., Ringden O., Einsele H. “A prospective randomized controlled trial comparing PCR-based and empirical treatment with liposomal amphotericin B in patients after allo-SCT”. 2009, Bone Marrow Transplantation, 43: 553-561
65. Ok M., Latgé J.P., Baeuerlein C., Ebel F., Mezger M., Topp M., Kurzai O., Killian D., Kapp M., Grigoleit G.U., Sennefelder H., Arroyo J., Einsele H., Loeffler J. “Immune responses of human immature dendritic cells can be modulated by the recombinant Aspergillus fumigatus antigen Aspf1″. 2009, Clinical and Vaccine Immunology 16: 1485-1492
66. Mezger M., Bonin M., Kessler T., Gebhardt F., Einsele H., Loeffler J. “Toll Like receptor 3 has no critical role during early immune response of human monocyte-derived dendritic cells after infection with the human cytomegalovirus strain TB40E”. 2009, Viral Immunology 22: 343-351
67. Morton C., Loeffler J., de Luca, A., Frost S., Kenny C., Duval S., Romani L., Rogers T. “Dynamics of extracellular release of Aspergillus fumigatus DNA and galactomannan during growth in blood and serum”. 2009, Journal of Medical Microbiology, in press
68. Hornbach A., Heyken A., Schild L., Hube B., Loeffler J., Kurzai O. The glycosylphosphatidylinositol-anchored protease Sap9 modulated the interaction of Candida albicans with human neutrophils”. 2009, Infection and Immunity 77: 5216- 5224
69. Spinnler K., Mezger M., Steffens M., Senefelder H., Kurzai O., Einsele H., Loeffler J. “Role of Glycogen Synthase Kinase 3 (GSK-3) in innate immune response of human immature dendritic cells to Aspergillus fumigatus“. 2010, Medical Mycology, in press
70. White L., Bretagne S., Klingspor L., Melchers W., Mc Culloch E., Schulz B., Finnstrom N., Mengoli C., Barnes R., Donnelly P., Loeffler J. on behalf of the European Aspergillus PCR initiative. “Aspergillus PCR: One step closer to standardization”. 2010, Journal of Clinical Microbiology, in press
71. Kurzwelly D., Knop S., Guenther M., Loeffler J., Korfel A., Thiel E., Hebart H., Simon M., Weller M., Linnebank M., Herrlinger U. “Genetic variants of folate and methionine metabolism and PCNSL incidence in a German patient population”. 2010,
Journal of Neurooncology, in press
72. Loeffler J, Ok M., Morton O., Mezger M., Einsele H. “Genetic Polymorphisms in the Cytokine and Chemokine System: Their Possible Importance in Allogeneic Stem Cell Transplantation”. 2010, Current Topics in Microbiology and Immunology, 341: 83- 96
73. Mezger M., Einsele H., Loeffler J. „Genetic susceptibility to infections with Aspergillus fumigatus“. 2010, Current Reviews in Microbiology, 36: 168-177
74. White L., Perry M., Loeffler J., Melchers W., Klingspor L., Bretagne S., McCulloch E., Cuenca-Estrella M., Finnstrom N., Donnelly P., Barnes R. on behalf of the European Aspergillus PCR Initiative.”Critical stages of extracting DNA from Aspergillus fumigatus in whole blood specimens”. 2010, Journal of Clinical Microbiology, 48: 3753-3756
75. McCormick A., Heesemann, L., Wagener J., Marcos V., Hartl D., Loeffler J., Heesemann J., Ebel F. „NETs formed by human neutrophils inhibit growth of the pathogenic mould Aspergillus fumigatus”. 2010, Microbes and Infection, in press
76. Dannoui E., Schwarz P., Slany M., Loeffler J., Jorde A., Cuenca-Estrella M., Hasuer P., Shrief R., Huerre M., Freiberger T., Gaustrad P., Rodriguez-Tudela J., Bille J., Denning D., Bretagne S., Lortholary O. “Molecular detection and identification of Zygomycetes species from paraffin-embedded tissues in a murine model of disseminated zygomycosis: a collaborative European Society of Clinical Microbiology and Infectious Diseases (ESCMID) fungal infection study group (EFISG) evaluation”. 2010, Journal of Clinical Microbiology 48: 2043-2046
77. Hebart H., Lengerke C., Ljungman P., Paya C., Klingebiel T., Loeffler J., Pfaffenrath S., Lewensohn-Fuchs I., Barkholt L., Tomiuk J., Meisner C., Lunenberg J., Top B., Razonable R., Patel R., Litzow M., Jahn G., Einsele H. “Prospective comparison of PCR-based versus late mRNA-based preemptive antiviral therapy for HCMV infection in patients after allo-SCT”. 2010, Bone Marrow Transplantation, in press
78. McCormick A., Loeffler J., Ebel F. “Aspergillus fumigatus: contours of a human fungal pathogen”. 2010, Cellular Microbiology, 11: 1535-1543
79. Springer J., Loeffler J., Heinz W., Schlossnagel H., Lehmann M., Morton O., Rogers T., Schmitt C., Frosch M., Einsele H., Kurzai O. „Pathogen specific DNA enrichment does not increase sensitivity of PCR for diagnosis of invasive aspergillosis in neutropenic patients”. 2011, Journal of Clinical Microbiology, 49: 1267-1273
80. Flechsig C., Suezer Y., Kapp M., Tan S., Loeffler J., Sutter G., Einsele H., Grigoleit G.U. “Uptake of antigens from modified vaccinia Ankara virus-infected leukocytes enhances the immunostimulatory capacity of dendritic cells”. 2011, Cytotherapy, in press
81. Loeffler J., Barnes R., Donnelly P. “Standardization of Aspergillus PCR diagnosis”. 2011, Bone Marrow Transplantation, in press
82. Morton O., Varga J., Hornbach A., Mezger M., Sennefelder H., Kneitz S., Kurzai O., Krappmann S., Einsele H., Nierman W., Rogers T., Loeffler J. “The temporal dynamics of differential gene expression in Aspergillus fumigatus interacting with human immature dendritic cells in vitro. 2011, PLoS ONE, 6: e16016
83. Beyrich C., Loeffler J., Kobsar A., Speer C., Kneitz S., Eigenthaler M. “Infection of human coronary artery endothelial cells by group B Streptococcus contributes to dysregulation of apoptosis, hemostasis and innate immune responses”. 2011, Mediators of Inflammation, doi:10.1155/2011/971502
84. Staab A., Fleischer M., Loeffler J., Said H., Katzer A., Plathow C., Einsele H., Flentje M., Vordermark D. “Small interfering RNA targeting HIF-1alpha reduces hypoxia-dependent transcription and radiosensitizes hypoxic HT 1080 human fibrosarcoma cells in vitro“. 2011, Strahlentherapie und Onkologie, 187: 252-259
85. Stuehler C., Khanna N., Bozza S., Zelante T., Moretti S., Kruhm M., Lurati S., Conrad B., Worschech E., Stevanovic S., Krappmann S., Einsele H., Latgé J.P., Loeffler J., Romani L., Topp M. “Cross-protective Th1 immunity against Aspergillus fumigatus and Candida albicans“. 2011, Blood, in press
86. Morton O., Clemons K., Springer J., Mueller J., Rogers T., Stevens D., Kurzai O., Einsele H., Loeffler J. “Real-time PCR and quantitative culture for monitoring experimental Aspergillus fumigatus intracranial infection in neutropenic mice”. 2011. Journal of Medical Microbiology, 60: 913-919
87. Bouzani M., Ok M., McCormick A., Ebel F., Kurzai O., Morton O., Einsele H., Loeffler J. “Human NK cells display important antifungal activity against Aspergillus fumigatus, which is directly mediated by Interferon gamma release”. 2011, Journal of Immunology, in press
88. Bauer R., Mezger M., Blockhaus C., Schmitt AL., Kurzai O., Einsele, H., Loeffler J. „40-O-[2-Hydroxyethhly] modulates human dendritic cell function during exposure to Aspergillus fumigatus“. 2011, Journal of Basic Microbiology, in press
89. White L., Mengoli C., Bretagne S., Cuenca Estrella M., Finnstrom N., Klingspor L., Melchers W., McCulloch E., Barnes R., Donnelly P., Loeffler J., on behalf of the European Aspergillus PCR Initiative. „An evaluation of Aspergillus PCR protocols for testing serum specimens”. 2011. Journal of Clinical Microbiology, in press
90. Ok M., Einsele H., Loeffler J. „Genetic susceptibility to Aspergillus fumigatus infections” 2011,. International Journal of Medical Microbiology 301: 445-452
91. Bouzani M., Einsele H., Loeffler J. „Functional analysis is a paramount prerequisite for understanding the in vitro interaction of human Natural Killer cells with Aspergillus fumigatus“. 2012, Journal of Infectious Diseases, in press
92. Springer J., Einsele H., Loeffler J. „Molecular techniques in the diagnosis of deep and systemic mycoses”. 2012, Clinics in Dermatology, in press
93. Donat S., Hasenberg M., Schäfer T., Ohlsen K., Gunzer M., Einsele H., Loeffler J., Beilhack A., Krappmann S. „Surface display of Gaussia princeps luciferase allows sensitive fungal pathogen detection during cutaneous aspergillosis”. 2012, Virulence, in press
94. Springer J., Schloßnagel H., Heinz W., Doedt T., Soeller R., Einsele H., Loeffler J., „A novel method combining plasma with a whole blood fraction shows excellent sensitivity and reproducibility for patients at high risk for invasive aspergillosis”. 2012, Journal of Clinical Microbiology 50: 2585-2591
95. Kapp M., Schargus M., Deuchert T., Springer J., Wendel F., Loeffler J., Grigoleit G., Kurzai O., Heinz W., Einsele H., Stuhler G. „Endophthalmitis as a primary clinical manifestation of fatal fusariosis in an allogeneic stem cell transplant recipient”. 2011, Transplantation Infectious Diseases 13: 374-379
96. Reichard U., Buchheidt D., Lass-Flörl C., Loeffler J., Lugert R., Ruhnke M., Tintelnot K., Weig M., Groß U. „Interlaboratory comparison of PCR-based identification of Candida and Aspergillus DNA in spiked blood samples”. 2012, Mycoses 55: 426-434
97. Morton O., Bouzani M., Loeffler J., Rogers T. “Direct interaction studies between Aspergillus fumigatus and human immune cells; what have we learned about pathogenicity and host immunity. 2012, Frontiers in Microbiology 3:413
98. Maschmeyer G., Heinz W., Hertenstein B., Horst A., Requadt C., Wagner T., Cornely O., Loeffler J., Ruhnke M. „Immediate versus deferred empirical antifungal (IDEA) therapy in high-risk aptients with febrile neutropenia: a randomized, double-blind, placebo-controlled multicentre study”. 2013, European Journal of Clinical Microbiology and Infectious Diseases, 32: 679 – 689
99. Rogers T., Morton O., Springer J., Conneally E., Heinz W., Kenny C., Frost S., Einsele H., Loeffler J. “Combined real-time PCR and galactomannan surveillance improves diagnosis of invasive aspergillosis in high risk patients with haematological malignancies” 2013, British Journal of Haematology, in press
100. Mueller-Loebnitz C., Ostermann H., Franzke A., Loeffler J., Uharek L., Topp M., Einsele H. „Immunological aspects of Candida and Aspergillus systemic fungal infections”. 2013, Interdisciplinary Perspectives on Infectious Diseases, in press
101. Springer J., Morton O., Perry M., Heinz W., Paholcsek M., Alzheimer M., Rogers T., Barnes R., Einsele H., Loeffler J., White L. “Comparison of serum and whole blood specimens for the detection of Aspergillus DNA in high-risk haematological patients: A multicenter evaluation”. 2013, Journal of Clinical Microbiology, in press
102. Tan S.M., Kapp M., Flechsig C., Kapp K., Rachor J., Eyrich M., Loeffler J., Einsele H., Grigoleit U. “Stimulating surface molecules, Th1-polarizing cytokines, proven trafficking-a new protocol for the generation of clinical-grade dendritic cells”. 2013, Cytotherapy, in press
103. Lyon G., Abdul-Ali D., Loeffler J., White L., Wickes B,, Herrera M., Alexander B., Baden L., Clancy C., Denning D., Hong Ngyuen M., Sugrue M., Wheat J., Wingrad J., Donnelly P., Barnes R., Patterson T., Caliendo A. “Development and evaluation of a calibrator material for nucleic acid based assays for diagnosing aspergillosis”. 2013, Journal of Clinical Microbiology 51: 2403-2405
104. Grube M., Loeffler J., Mezger M., Krüger B., Echtenacher B., Hoffmann P., Edinger M., Einsele H., Andreesesn R., Holler E. „TLR5 stop codon polymorphism is associated with invasive aspergillosis after allogeneic stem cell transplantation”. 2013, Medical Mycology, in press
105. Voigt J., Huenniger K., Bouzani M., Jacobsen I., Barz D., Hube B., Löffler J., Kurzai O. “Human NK cells act as phagocytes against Candida albicans and mount an inflammatory response which modulates neutrophil antifungal activity”. 2014, Journal of Infectious Diseases, in press
106. Cunha C., Aversa F., Lacerda J., Busca A., Kurzai O., Grube M., Löffler J., Maertens J., Bell A., Inforzato A., Barbati E., Almeida B., Santos e Sousa P., Barbui A., Potenza L., Caira M., Rodrigues F., Salvatori G., Pagano L., Luppi M., Mantovani A., Velardi A., Romani L., Carvalho A. “Genetic PTX3 deficiency and aspergillosis in stem cell transplantation”. 2014, New England Journal of Medicine 370: 421-432
107. Semmlinger A., Fliesser M., Waaga-Gasser A. Dragan M., Morton O., Einsele H., Loeffler J. „Fever-range temperature modulates activation and function of human dendritic cells stimulated with the pathogenic mould Aspergillus fumigatus“. 2014, Medical Mycology, in press
108. Morton O., Fliesser M., Dittrich M., Mueller T., Bauer R., Kneitz S., Hope W., Rogers T., Einsele H., Loeffler J. „Gene expression profiles of human dendritic cells interacting with Aspergillus fumigatus in a bilayer model of the alveolar epithelial/endothelial interface”. 2014, PLOS One 9e98279
109. Das Gupta M., Fliesser M., Springer J., Breitschopf T., Schlossnagel H., Schmitt A., Kurzai O., Hünniger K., Einsele H., Löffler J. „Aspergillus fumigatus induces microRNA-132 in human monocytes and dendritic cells”. 2014, International Journal of Medical Microbiology, in press
110. Lother J., Breitschopf T., Krappmann S., Morton O., Bouzani M., Kurzai O., Gunzer M., Hasenberg M., Einsele H., Loeffler J. „Human dendritic cell subsets display distinct interactions with the pathogenic mould Aspergillus fumigatus“. 2014, International Journal of Medical Microbiology, in press
111. Cunha C., Kurzai O., Löffler J., Aversa F., Romani L., Carvalho A. “Neutrophil responses to Aspergillosis: New roles for old players”. 2014, Mycopathologia 178: 387-393
112. Hünniger K., Bieber K., Martin R., Lehnert T., Figge T., Löffler J., Guo R., Riedemann N., Kurzai O. „A second stimulus required for enhanced antifungal activity of human neutrophils in blood is provided by anaphylatoxin C5a”. 2014, Journal of Immunology, in press
113. Rieber N., Singh A., Carevic M., Öz H., Bouzani M., Amich J., Ost M., ye, Z., Schäfer I., Mezger M., Klimosch S., Weber A., Handgretinger R., Liese J., Engeholm M., Schüle R., Salih H., Marodi L., Speckmann C., Grimbacher B., Ruland J., Brown G., Beilhack A., Loeffler J., Hartl D. “Pathogenic fungi regulate T-cell immunity by including neutrophil myeloid-derived suppressor cells through a dectin-1 / CARD9 and ROS-mediated mechanisms”. 2015, Cell Host and Microbe, in press
114. Loeffler C., Kapp M., Grigoleit U., Mielke S., Loeffler J., Heuschmann P., Malzahn U., Hupp E., Einsele H., Stuhler G. “Control of relapsed or refractory acute myeloid leukemia by clofarabine in preparation for allogeneic stem cell transplantation”. 2015, Leukemia and Lymphoma, in press
115. Leonhardt I., Spielberg S., Weber M., Albrecht-Eckardt D., Bläss M., Claus R., Barz D., Löffler J., Hünniger K., Kurzai O. “The fungal Quorum-Sensing-Molecule Farnesol activates innate immune cells but suppresses cellular adaptive immunity”, 2015, MBio, in press
116. Rambach G., Blum G., Latge J., Fontaine T., Heinekamp T., Hagleitner M., Jeckström H., Weigel G., Würtinger P., Pfaller K., Krappmann S., Löffler J., Lass-Floerl C., Speth C. „Identification of Aspergillus fumigatus surface components that mediate interaction of conidia and hyphae with human platelets”. 2015, Journal of Infectious Diseases, in press
117. Mueller-Leisse J., Brueggemann S., Bouzani M., Schmitt A., Einsele H., Loeffler J. “Polymorphonuclear Neutrophils and Granulocytic Myeloid-Derived Suppressor Cells Inhibit Natural Killer Cell Activity Towards Aspergillus fumigatus“, 2015, Medical Mycology, in press
118. Einsele H., Löffler J., Kapp M., Rasche L., Mielke S., Grigoleit U. „Immunotherapy for viral and fungal infections”. 2015, Bone Marrow Transplantation, in press
119. Löffler C., Löffler J., Kobsar A., Speer S., Eigenthaler M. „Septic versus colonizing Group B Streptococci differentially regulate inflammation and apoptosis in human coronary artery endothelial cells – a pilot study”. 2015, Journal of Pediatrics and Neonatal Care, in press
120. White L., Barnes R., Springer J., Klingspor L., Cuenca-Estrella M., Morton O., Lagrou K., Bretagne S., Melchers W., Mengoli C., Donnelly P., Heinz W., Loeffler J. and the EAPCRI. “The clinical performance of Aspergillus PCR when testing serum and plasma- a study by the European Aspergillus PCR Initiative”, 2015, Journal of Clinical Microbiology, in press
121. Loeffler J., Mengoli C., Springer J., Bretagne S., Cuenca Estrella M., Klingspor L., Lagrou K., Melchers W., Morton O., Barnes R., Donnelly P., White L., on behalf of the European Aspergillus PCR Initiative. “Analytical comparison of in vitro spiked human serum and plasma for the PCR-based detection of Aspergillus fumigatus DNA – a study by the European Aspergillus PCR Initiative”, 2015, Journal of Clinical Microbiology, in press
122. White L., Wingard J., Bretagne S., Loeffler J., Patterson T., Slavin M., Barnes R., Pappas P., Donnelly P. “Aspergillus PCR: a systematic review of evidence for clinical use in comparison with antigen testing”, 2015, Clinical Infectious Diseases, in press
123. Paholcsek M., Fidler G., Kónya J., Rejto L., Méhes G., Bukta E., Loeffler J., Biró S. “Combining standard clinical methods with PCR showed improved diagnosis of invasive pulmonary aspergillosis in patients with hematological malignancies and prolonged neutropenia”, 2015, BMC Infectious Diseases, in press
124. Beitzen-Heineke A., Bouzani M., Schmitt A., Kurzai O., Huenniger K., Einsele H., Loeffler J. „Invariant Natural Killer T cells possess immune-modulating functions during Aspergillus fumigatus infection”, 2015 Medical Mycology, in press
125. Fliesser M., Morton O., Bonin M., Ebel F., Hünniger K., Kurzai O., Einsele H., Löffler J. „Hypoxia-inducible factor 1α modulates metabolic activity and cytokine release in anti-Aspergillus fumigatus immune responses initiated by human dendritic cells”, 2015, International Journal of Medical Microbiology, in press
126. Cruciani M., Mengoli C., Loeffler J., Donnelly P., Barnes R., Jones B., Klingspor L., Morton O., Maertens J. “Polymerase chain reaction blood tests for the diagnosis of invasive aspergillosis in immunocompromised people”, 2015, Cochrane Database of Systematic Reviews, Issue 9. Art. No.: CD009551
127. Springer J., Lackner M., Nachbaur D., Girschikofsky M., Risslegger B., Mutschlechner W., Fritz J., Heinz W., Einsele H., Ullmann A., Loeffler J., Lass-Florl C., “Prospective multicenter PCR-based Aspergillus DNA screening in high risk patients with and without primary antifungal mold prophylaxis”, 2015, Clinical Microbiology and Infection, in press
128. Irmer H., Tarazona S., Sasse C., Olbermann P., Loeffler J., Krappmann S., Conesa A., Braus G. „RNAseq analysis of Aspergillus fumigatus in blood reveals a just wait and see resting stage behavior”, 2015, BMC Genomics, 16: 640-665
129. Lupianez C., Canet L., Carvalho A., Alcazar-Fuoli C., Springer J., Lackner M., Segura-Catena J., Comino A., Olmedo C., Rios R., Fernández-Montoya A., Cuenca-Estrella M., Solano C., Lopez-Nevot M., Cunha C., Oliveira-Coelho A., Villaescusa C., Fianchi L., Aguado J., Pagano L., Lopez-Fernandez L., Potenza L., Luppi M., Lass-Flörl C., Löffler J., Einsele H., Vázquez L., Study Group PCRAGA, Jurado M., Sainz J. “Polymorphisms in host immunity modulating genes and risk of invasive aspergillosis: Results from the aspBIOmics consortium”, 2015, Infection and Immunity, in press
130. Springer J., White L., Hamilton S., Michel D., Barnes R., Einsele H., Löffler J. “A comparison of the performance of Aspergillus PCR when testing a range of blood based samples in accordance with international methodological recommendations”, 2016, Journal of Clinical Microbiology, in press
131. Springer J., Goldenberger D., Schmidt F., Weisser M., Wehrle-Wieland E., Einsele H., Frei R., Loeffler J. “Development and application of two independent real-time PCR assays to detect clinically relevant Mucorales species”, 2016, Journal of Medical Microbiology, in press
132. White L., Wiederhold N., Loeffler J., Najvar L., Melchers W., Herrera M., Bretagne S., Wickes B., Kirkpatrick W., Barnes R., Donnelly P., Patterson T. “A comparison of the non-culture blood-based tests for diagnosing invasive aspergillosis in an animal model”, 2016, Journal of Clinical Microbiology, in press
133. Dix A., Czakai K., Springer J., Fliesser M., Bonin M., Guthke R., Schmitt A., Einsele H., Linde J., Löffler J. “Genome-wide Expression Profiling Reveals S100B as Biomarker for Invasive Aspergillosis”, 2016, Frontiers in Microbiology, in press
134. Fliesser M., Wallstein M., Kurzai O., Einsele H., Loeffler J. “Hypoxia attenuates anti-Aspergillus fumigatus immune responses initiated by human dendritic cells”, 2016, Mycoses, in press
135. Teutschbein J., Simon S., Lother J., Springer J., Hortschansky P., Morton O., Löffler J., Einsele H., Conneally E., Rogers T., Guthke R., Brakhage A., Kniemeyer O. “Proteomic profiling of serological responses to Aspergillus fumigatus antigens in patients with invasive aspergillosis”, 2016, Journal of Proteome Research, in press
136. Hellwig D., Voigt J., Bouzani M., Löffler J., Albrecht-Eckardt D., Weber M., Brunke S., Martin R., Kurzai O., Hünniger K. “Candida albicans induces Metabolic Reprogramming in human NK cells and responds to Perforin with a Zinc Depletion Response”, 2016, Frontiers in Microbiology, in press
137. Czakai K, Leonhardt I, Dix A, Bonin M, Linde J, Einsele H, Kurzai O, Loeffler J. “Krüppel-like Factor 4 modulates interleukin-6 release in human dendritic cells after in vitro stimulation with Aspergillus fumigatus and Candida albicans“. 2016. Nature Scientific Reports.6: 27990. doi: 10.1038/srep27990.
138. Morton O. White L., Barnes R., Klingspor L., Cuenca-Estrella M., Lagrou K. Bretagne S., Melchers W., Mengoli C., Caliendo A., Cogliati M., Debets Y., Gorton R., Hagen F., Halliday C., Hamal P., Harvey-Wood K., Jaton K., Johnson G., Kidd S., Lengerova M., Lass-Flörl C., Linton C., Millon L., Morrissey O., Paholcsek M., Talento A., Ruhnke M., Willinger B., Donnelly P., Loeffler J. “Determining the analytical specificity of PCR-based assays for the diagnosis of IA: what is Aspergillus?”, 2016, Medical Mycology, in press
139. Lupiañez C., Villaescusa M., Carvalho A., Springer J., Lackner M., Sánchez-Maldonado J., Canet L., Cunha C., Segura-Catena J., Alcazar-Fuoli L., Solano C., Fianchi L., Pagano L., Potenza L., Aguado J., Luppi M., Cuenca-Estrella M., Lass-Flörl C., Einsele H., Vázquez L., PCRAGA Study Group, Ríos-Tamayo R., Loeffler J., Jurado M., Sainz J. “Common genetic polymorphisms within NFκB-related genes and the risk of developing invasive aspergillosis”, 2016, Frontiers in Microbiology, in press
140. Hefter M., Lother J., Weiß E., Schmitt A:, Fliesser M., Einsele H., Loeffler J. „Human primary myeloid dendritic cells interact with the opportunistic fungal pathogen Aspergillus fumigatus via the C type lectin receptor Dectin-1″, 2016, Medical Mycology, in press
141. Loeffler J., Hafner J., Mengoli C., Wirth C., Heussel C., LöfflerC., White L., Ullmann A., Michel M., Wiegering V., Wölfl M., Schlegel P., Einsele H., Springer J., Eyrich, M. “Prospective biomarker screening for the diagnosis of invasive aspergillosis in high-risk paediatric patients”, 2016, Journal of Clinical Microbiology, in press
142. Fuji S., Loeffler J., Savani B., Einsele H., Kapp M. „Hyperglycemia as a possible risk factor for mold infections – the potential preventative role of intensified glucose control in allogeneic hematopoietic stem cell transplantation”, 2016, Bone Marrow Transplantation, in press
143. Czakai K., Dittrich M., Kaltdorf M., Müller M., Krappmann S., Schedler A., Bonin M., Dühring S., Schuster S., Speth C., Rambach G., Einsele H., Dandekar T., Löffler J. „Influence of Platelet-rich Plasma on the immune response of human monocyte-derived dendritic cells and macrophages stimulated with Aspergillus fumigatus“, 2016, International Journal of Medical Microbiology, in press
144. Dix A., Czakai K., Leonhardt I., Schäferhoff K., Bonin M., Guthke R., Einsele H., Kurzai O., Löffler J.*, Linde J. “Specific and novel microRNAs are regulated as response to fungal infection in human dendritic cells”, 2017, Frontiers in Microbiology, in press
145. Cunha C., Duarte-Oliveira C., Gonçalves S., Leite L., Lagrou K., Marques A, Lupiañez C., Barbosa A., Gaifem J., Mesquita I., Vaz C., Branca R., Campilho F., Freitas F., Ligeiro D., Lass-Flörl C., Löffler J., Jurado M., Saraiva M., Kurzai O., Rodrigues F., Castro A., Silvestre R., Sainz J., Maertens J., Torrado E., Jacobsen I., Lacerda J., Campos A, Carvalho A. “IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity”, 2017, Journal of Allergy and Clinical Immunology, in press
146. Talento A., Dunne K., Joyce, E., Palmer E., Johnson E., White L., Springer J. Loeffler J. Ryan T., Collins D., Rogers T. “A prospective study of fungal biomarkers to improve management of invasive fungal diseases in a mixed specialty critical care unit”, 2017, Journal of Critical Care, in press
147. Wurster S., Thielen V., Weis P., Walther P., Elias J., Waaga-Gasser A., Dragan M., Dandekar T., Einsele H., Löffler J., Ullmann A. „Mucorales spores 1 induce a proinflammatory cytokine response in human mononuclear phagocytes and harbor no rodlet hydrophobins”, 2017, Virulence, in press
148. Barnes R., White L. Morton O., Rogers T., Cruciani M., Loeffler J., Donnelly P. “Aspergillus PCR in Practice: Clinical Considerations and Technical Tips”, 2017, Medical Mycology, in press
149. Decker C., Wurster S., Lazariotou M., Hellmann A., Einsele H., Ullmann A., Löffler J. „Analysis of the in-vitro activity of human neutrophils against Aspergillus fumigatus in presence of antifungal and immuno-suppressive agents”, 2017, Medical Mycology, in press
150. Ziegler S., Weiss E., Schmitt A., Schlegel J., Burgert A., Terpitz U., Sauer M., Moretta L., Sivori S., Leonhardt I., Kurzai O., Einsele H., Loeffler J. „CD56 Is a Pathogen Recognition Receptor on Human Natural Killer Cells”, 2017, Scientific Reports, in press
151. Saraiva J., Oswald M., Biering A., Röll D., Assmann C., Klassert T., Blaess M., Czakai K., Claus R., Löffler J., Slevogt H., König R., „Fungal biomarker discovery by integration of classifiers“, 2017, BMC Genomics 18: 601 doi: 10.1186
152. Springer J., White L., Kessel J., Wieters I., Teschner D., Korczynski D., Liebregts T., Cornely O., Schwartz S., Elgeti T., Meintker L., Krause S., Posso R., Heinz1 W., Fuhrmann S., Vehreschild J., Einsele H., Rickerts V., Loeffler J. „A Multi-Centre Comparison of Aspergillus and Mucorales PCR Testing of different BAL Fractions”, 2017, Journal of Clinical Microbiology, in press
153. Hellmann A., Lother J., Wurster S., Lutz M., Schmitt1 A., Morton O., Eyrich M., Czakai K., Einsele H., Loeffler J. „Human and murine innate immune cell populations display common and distinct response patterns during their in vitro interaction with the pathogenic mould Aspergillus fumigatus”, 2017, Frontiers in Immunology, in press
154. Ullmann A., Aguado J., Arikan S., Denning D Groll A., Lagrou K., Lass-Florl C., Lewis R., Muñoz P., Verweij P., Warris A. Akova M., Arendrup M., Barnes R., Blot S., Bouza E., Brüggemann R., Buchheidt D. Cadranel J., Chakrabarti A., Cuenca-Estrella M., Dimopoulos G., Gangneux J., Garbino J., Heinz W., Herbrecht R., Kibbler C., Klimko N. Kullberg B., Lange C., Lehrnbecher T., Loeffler J., Lortholary O., Maertens J., Cornely O. “Diagnosis and Management of Aspergillus Diseases: Executive Summary of the 2017 ESCMID-ECMM-ERS Guideline”, 2018, Clinical Microbiology and Infection, in press
155. Lauruschkat C., Wurster S. Page L., Lazariotou M., Dragan M., Weis P., Ullmann A., Einsele H., Löffler J., “Susceptibility of A. fumigatus specific T-cell assays to pre-analytic blood storage and PBMC cryopreservation greatly depends on readout platform and analytes”, 2018, Mycoses, in press
156. Springer J., McCormick Smith I., Hartmann S., Winkelmann R., Wilmes D., Cornely O., Kessel J., Löffler J., Rickerts V., „Identification of Aspergillus and Mucorales in Formalin-Fixed, Paraffin-Embedded Tissue Samples: Comparison of Specific and Broadrange Fungal qPCR Assays”, 2018, Medical Mycology, in press
157. White, L., Barnes, R., Gorton R., Cruciani M., Loeffler J., “COMMENT ON: T2Candida MR as a predictor of outcome in patients with suspected invasive candidiasis starting empirical antifungal treatment: a prospective pilot study”, 2018, Journal of Antimicrobial Chemotherapy, in press
158. Voltersen V., Blango M., Herrmann S., Schmidt F., Heinekamp T., Strassburger M., Krüger T., Bacher P., Lother J., Weiss E., Hünniger K., Liui H., Hortschansky P., Scheffold A., Löffler J., Krappmann S., Nietzschek S., Kurzai O., Einsele H., Kniemeyer O., Filler S., Reichard U., Brakhage A., „Proteome analysis reveals the conidial surface protein CcpA essential for virulence of the pathogenic fungus Aspergillus fumigatus”, 2018, mBIO, in press
159. Weiss E., Ziegler S., Fliesser M., Schmitt A., Huenniger K., Kurzai O., Morton O., Einsele H., Loeffler J., „First insights in NK – DC cross-talk and the importance of soluble factors during infection with Aspergillus fumigatus”, 2018, Frontiers in Cellular and Infection Microbiology, in press
160. Morton O., Wurster S., Fliesser M., Ebel F., Page L., Hünniger K., Kurzai O., Schmitt A., Michel D., Springer J., Einsele H., Loeffler J., „Validation of a simplified in vitro Transwell® model of the alveolar surface to assess host immunity induced by different morphotypes of Aspergillus fumigatus”, 2018, International Journal of Medical Microbiology, in press
161. Page L., Weis P., Mueller T., Dittrich M., Lazariotou M., Dragan M., Waaga-Gasser A., Helm J., Dandekar T., Loeffler J., Ullmann A., Einsele H., „Evaluation of Aspergillus and Mucorales specific T-cells and PBMC cytokine signatures as biomarkers of environmental mold exposure”, 2018, International Journal of Medical Microbiology, in press
162. Hoenigl M., Oraschd T., Faserle K., Prattes J., Loeffler J., Springer J., Gsallerd, F., Reischies F., Duettmann W., Raggam R., Lindner H., Haas H., “Triacetylfusarinine C: a urine biomarker for diagnosis of invasive aspergillosis”, 2018, Journal of Infection, in press
163. Caetano L., Faria T., Springer J., Loeffler J., Viegas C., “Antifungal drug-resistance in Mucorales in different indoor environments”, 2018, Mycology: An International Journal on Fungal Biology, in press
164. Loeffler J., Ebel, F. “Size matters – how the immune system deals with fungal hyphae, 2018, Microbes and Infection, in press
165. Belic S., Page L., Lazariotou M., Waaga-Gasser A., Dragan M., Springer J., Loeffler J., Morton O., Einsele H., Ullmann A., Wurster S., Comparative analysis of inflammatory cytokine release and alveolar epithelial barrier invasion in a Transwell® bilayer model of mucormycosis, 2018, Frontiers in Microbiology, in press
166. Lauruschkat C., Einsele H., Loeffler J., Immunomodulation as a Therapy for Aspergillus Infection: Current Status and Future Perspectives, 2018, Journal of Fungi, in press
167. Marischen L., Englert A., Schmitt A. Einsele H., Loeffler J., „Human NK cells adapt their immune response towards increasing multiplicities of infection of Aspergillus fumigatus”, 2018, BMC Immunology, in press
168. Srivastava M., Bencurova E., Gupta S., Weiss E., Loeffler J., Dandekar T., “Aspergillus fumigatus challenged by human dendritic cells: metabolic and regulatory pathway responses testify a tight battle”, 2019, Frontiers in Cellular and Infection Microbiology, in press
169. Cruciani M., Mengoli C., Barnes R., Donnelly P, Loeffler J., Jones B, Klingspor L, Maertens J, Morton O, White L., “Polymerase chain reaction blood tests for the diagnosis of invasive aspergillosis in immunocompromised people”, 2019, Cochrane Database Systematic Reviews, doi: 10.1002/14651858.CD009551
170. Weis P., Helm J., Page L., Lauruschkat C., Lazariotou M., Einsele H., Loeffler J., Ullmann A., Wurster S., “Development and evaluation of a whole blood-based approach for flow cytometric quantification of CD154+ mould-reactive T cells”, 2019, Medical Mycology, doi: 10.1093/mmy/myz038
171. Springer J., Walther G., Rickerts V., Hamprecht A., Willinger B., Teschner D., Einsele H., Kurzai O., Loeffler J., Detection of Fusarium species in clinical specimens by probe-based real-time PCR, 2019, Journal of Fungi, in press
172. Seif M., Einsele H., Loeffler J., „CAR T Cells beyond cancer: Hope for immunomodulatory therapy of infectious diseases”, 2019, Frontiers in Immunology
173. Zoran T., Weber M., Springer J., White L., Bauer J., Schober A., Löffler C., Seelbinder B., Hünniger K., Kurzai O., Scherag A., Schäuble S., Morton O., Einsele H., Linde J., Loeffler J., „Treatment with etanercept and low monocyte concentration contribute to the risk of invasive aspergillosis in patients post allogeneic stem cell transplantation”, 2019, Scientific Reports, in press
174. Gits-Muselli M., White L., Mengoli C., Chen S., Crowley B., Dingemans G., Frealle E., Gorton R., Guiver M., Hagen F., Halliday C., Johnson G., Lagrou K., Lengerova M., Melchers W., Novak-Fraser L., Rautemaa-Richardson R., Scherer E., Steinmann J., Cruciani M., Barnes R., Donnelly P., Loeffler J., Bretagne S., Alanio A., “The Fungal PCR Initiative`s evaluation of in-house and commercial Pneumocyctis jirovecii qPCR assays: towards a standard for a diagnostics assay”, 2020, Medical Mycology, 58: 779-788
175. Lupianze C., Martínez-Bueno M., Sánchez-Maldonado J., Badiola J., Cunha C., Springer J., Lackner M., Segura-Catena J., Canet L., Alcazar-Fuoli L., Lopez-Nevot J., Fianchi L., Aguado J., Pagano L., López-Fernández E., Alarcón-Riquelme M., Potenza L., Gonçalves S., Luppi M., Moratalla L., Solano C., Sampedro A., González-Sierra P., Cuenca-Estrella M., Lagrou K., Maertens J., Lass-Flörl C., Einsele H., Vázquez L., Study Group PCRAGA, Löffler J., Rios R., Carvalho A., Jurado M., Sainz J., “Polymorphisms within the ARNT2 and CX3CR1 genes are associated with the risk of developing invasive aspergillosis”, 2020, Infection and Immunity, 88: e00882-19
176. Marolda A., Hünniger K:, Böttcher S., Vivas W., Löffler J., Figge T., Kurzai O., “Candida species-dependent release of IL-12 by dendritic cells induces different levels of NK cell stimulation”, 2020, Journal of Infectious Diseases, in press
177. White L., Alanio A., Cruciani M., Gorton R., Millon L., Rickerts V., Barnes R., Donnelly P., Loeffler J., “Nucleic Acid tools for Invasive Fungal Disease Diagnosis”, 2020, Current Fungal Infection Reports, in press
178. Springer J., Löffler J., Einsele H., White L., „The screening of blood by Aspergillus PCR and Galactomannan ELISA precedes BAL detection in patients with proven and probable IA”, 2020, Medical Mycology, 58: 856-858
179. Weiss E., Schlegel J., Terpitz U., Weber M., Linde J., Schmitt A., Hünniger K., Marischen L., Gamon F., Bauer J., Löffler C., Kurzai O., Morton O., Sauer M., Einsele H., Loeffler J. „Reconstituting NK Cells After Allogeneic Stem Cell Transplantation Show Impaired Response to the Fungal Pathogen Aspergillus fumigatus.”, 2020, Frontiers in Immunology, 11: 2117
180. Seelbinder B., Wallstabe L., Marischen L., Weiss E., Wurster S., Page L., Löffler C., Bussemer L., Schmitt A., Wolf T., Linde J., Cicin-Sain L., Becker J., Kalinke U., Vogel J., Panagiotou G., Einsele H., Westermann A., Schäuble S., Loeffler J. „Triple RNA-Seq reveals synergy in a human virus-fungus co-infection model“, 2020, Cell Reports, 33: 108389
181. Seif M., Häder A., Löffler J., Kurzai O. ”From Bench to Bedside – Translational Approaches in Anti-fungal Immunology”, 2020, Current Opinion in Microbiology, 58: 153-159
182. Cruciani M., White L. Mengoli C., Loeffler J., Morton O., Klingspor L., Buchheidt D., Maertens J., Heinz W., Rogers T., Weinbergerova B., Warris A., Lockhart D., Jones B., Cordonnier C., Donnelly P., Barnes R. „The impact of anti-mold prophylaxis on Aspergillus PCR blood testing for the diagnosis of invasive aspergillosis”, 2020, Journal of Antimicrobial Chemotherapy, in press
183. Schmidt S., Ebner F., Rosen K., Kniemeyer O., Brakhage A., Löffler J., Seif M., Springer J., Schlosser J., Scharek-Tedin L., Scheffold A., Bacher P., Kühl A., Rösler U., Hartmann S. “The domestic pig as human-relevant large animal model to study adaptive antifungal immune response against airborne Aspergillus fumigatus”, 2020, European Journal of Infectious Diseases, 50: 1712-1728
184. Carvalho-Pereira J., Fernandes F., Araújo R., Springer J., Loeffler J., Buitrago M., Pais C., Sampaio P. “Multiplex PCR Based Strategy for Detection of Fungal Pathogen DNA in Patients with Suspected Invasive Fungal Infections”, 2020, Journal of Fungi, 6: 308
185. Sánchez-Maldonado J., Campa D., Springer J., Badiola J., Niazi Y., Moñiz-Díez A., Hernández-Mohedo F., González-Sierra P., Ter Horst R., Macauda A., Brezina S., Cunha C., Lackner M., López-Nevot M., Fianchi L., Pagano L., López-Fernández E., Potenza L., Luppi M., Moratalla L., Rodríguez-Sevilla J., Fonseca J., Tormo M., Solano C., Clavero E., Romero A., Li Y., Lass-Flörl C., Einsele H., Vazquez L., Loeffler J., Hemminki K., Carvalho A., Netea M., Gsur A., Dumontet C., Canzian F., Försti A., Jurado M., Sainz J. “Host immune genetic variations influence the risk of developing acute myeloid leukaemia: results from the NuCLEAR consortium”, 2020, Blood Cancer Journal 10: 75
186. White L., Bretagne S., Caliendo A., Loeffler J., Patterson T., Slavin M., Wingard J., “Aspergillus PCR – An update on technical recommendations, clinical applications and justification for inclusion in the second revision of the EORTC/MSGERC definitions of invasive fungal disease”, 2020, Clinical Infectious Diseases, in press
187. Sánchez-Maldonado J., Moñiz-Díez A., Horst R., Campa D., Cabrera-Serrano A., Martínez-Bueno M., del Pilar Garrido-Collado M., Hernández-Mohedo F. Fernández-Puerta F., Lopez-Nevot M., Cunha C., González-Sierra P., Springer J., Lackner M., Alcazar-Fuoli L., Fianchi L., Aguado J., Pagano L., López-Fernández L., Clavero E., Potenza L., Luppi M., Moratalla L., Solano C., Sampedro A., Cuenca-Estrella M., Lass-Flörl C., PCRAGA Study Group, Canzian F., Loeffler J., Li Y., Einsele H., Netea M., Vázquez L., Carvalho A., Jurado M., Sainz J., “Polymorphisms within the TNFSF4 and MAPKAPK2 loci influence the risk of developing invasive aspergillosis: a two-stage case control study in the context of the aspBIOmics consortium”, 2020, Journal of Fungi, in press
188. Page L., Lauruschkat C., Helm J., Weis P., Lazariotou M., Einsele H., Ullmann A., Loeffler J., Wurster S., “Impact of immunosuppressive and antifungal drugs on PBMC- and whole blood-based flow cytometric CD154+ Aspergillus fumigatus specific T-cell quantification”, 2020, Medical Microbiology and Immunology 209: 579-592
189. Donnelly J., Chen S., Kauffman C., Steinbach W., Baddley J., Verweij P., Clancy C., Wingard J., Lockhart S., Groll A., Sorrell T., Bassetti M., Akan H., Alexander B., Andes D., Azoulay E., Bialek R., Bradsher R., Bretagne S., Calandra T., Caliendo A., Castagnola E., Cruciani M., Cuenca-Estrella M., Decker C., Desai S., Fisher B., Harrison T., Heussel C., Jensen H., Kibbler C., Kontoyiannis D., Kullberg B., Lagrou K., Lamoth F., Lehrnb
190. Rocchi S., Scherer E., Mengoli C., Alanio A., Botterel F., Bougnoux M., Bretagne S., Cogliati M., Cornu M., Dalle F., Damiani C., Denis J., Fuchs S., Gits-Muselli M., Hagen F., Halliday C., Hare R., Iriart X., Klaassen C., Lackner M., Lengerova M., Letscher-Bru V., Morio F., Nourrisson C., Posch W., Sendid B., Springer J., Willinger B., White L., Barnes R., Cruciani M., Donnelly P., Loeffler J., Millon L, “Interlaboratory evaluation of Mucorales PCR assays for testing serum specimens: A study by the fungal PCR Initiative and the Modimucor study group”, 2020, Medical Mycology: myaa036. doi: 10.1093/mmy/myaa036
191. White L., Bretagne, S. Caliendo A., Loeffler J., Patterson T.,Slavin M., Wingard J. “Aspergillus Polymerase Chain Reaction—An Update on Technical Recommendations, Clinical Applications, and Justification for Inclusion in the Second Revision of the EORTC/MSGERC Definitions of Invasive Fungal Disease, 2021, Clinical Infectious Diseases, 72: S95-S101
192. Springer J., Held J., Mengoli C., Schlegel P., Gamon F., Träger J., Kurzai O., Einsele H., Loeffler J., Eyrich M., “Diagnostic Performance of (1→3)-β-D-Glucan Alone and in Combination with Aspergillus PCR and Galactomannan in Serum of Pediatric Patients after Allogeneic Hematopoietic Stem Cell Transplantation”, 2021, Journal of Fungi, 7, 238
193. Dunne M., Wagener J., Loeffler J., Doherty D., Rogers T. “Unconventional T cells – new players in antifungal immunity”, 2021, Clinical Immunology, in press
194. Page L., Wallstabe J., Lother J., Bauser M., Kniemeyer O., Strobel L., Voltersen V., Teutschbein J., Hortschansky P., Morton O., Brakhage A., Topp M., Einsele H., Wurster S., Loeffler J. “CcpA-and Shm2-pulsed myeloid dendritic cells induce T-cell activation and enhance the neutrophilic oxidative burst response to Aspergillus fumigatus”, 2021, Frontiers in Immunology, in press
195. Lauruschkat C., Page L., White L., Etter S., Davies H., Duckers , Ebel F., Schnack E., Backx M., Dragan M., Schlegel N., Kniemeyer O., Brakhage A., Einsele H., Loeffler J., Wurster S. “Development of a Simple and Robust Whole Blood Assay with Dual Co‐Stimulation to Quantify the Release of T‐Cellular Signature Cytokines in Response to Aspergillus fumigatus Antigens”, 2021, Journal of Fungi, in press
196. Lauruschkat C., Page L., Etter S., Weis P., Gamon F., Kraus S., Einsele H., Wurster S., Loeffler J., “T-Cell Immune Surveillance in Allogenic Stem Cell Transplant Recipients: Are Whole Blood–Based Assays Ready to Challenge ELISPOT?”, 2020, Open Forum Infectious Diseases, 8: ofaa547
197. Trinks N., Reinhard S., Drobny M,., Heilig L., Löffler J., Sauer M., Terpitz U., “Subdiffraction-resolution fluorescence imaging of immunological synapse formation between NK cells and fumigatus by expansion microscopy”, 2021, Communications Biology, in press
198. Zoran T., Seelbinder B., White L., Price J., Kraus S., Kurzai O., Linde J., Häder A., Loeffler C., Grigoleit U., Einsele H., Panagiotou G., Loeffler J*, Schäuble S.*, “Molecular profiling reveals characteristic and decisive signatures in patients after allogeneic stem cell transplantation suffering from invasive pulmonary aspergillosis”, 2021, Journal of Fungi, in press
199. White L., Springer J., Wise M., Einsele H., Löffler C., Seif M. , Prommersberger S., Backx M., Löffler J., “Clinical Case of COVID-19-Associated Pulmonary Aspergillosis (CAPA): Illustrating the Challenges in Diagnosis (despite Overwhelming Mycological Evidence)”, 2022, Journal of Fungi, in press
200. White, L. Alanio A., Brown L., Cruciani M., Hagen F., Gorton R., Lackner M., Millon L., Morton O., Richardson R., Barnes R., Donnelly P., Loeffler J. on behalf of the Fungal PCR Initiative. “An overview of using fungal DNA in diagnostics of invasive mycoses”, 2022, Expert Review of Molecular Diagnostics, in press
201. Henß I., Kleinemeier C., Strobel L., Brock M., Loeffler J., Ebel F. “Characterization of Aspergillus terreus accessory conidia and their interactions with murine macrophages”, 2022, Frontiers in Microbiology, in press
202. Maertens J., Lodewyck T., Donnelly P., Chantepie S., Blijlevens R., Turlure P., Selleslag D., Baron F., Aoun M., Heinz W., Bertz H., Ráčil Z., Vandercam B., Drgona L., Coiteux V., Llorente C., Schaefer-Prokop C., Paesmans M., Ameye L., Meert L., Cheung K., Hepler D., Loeffler J., Barnes R., Marchetti O., Verweij P., Lamoth F., Bochud P., Schwarzinger M., Cordonnier C., for the Infectious Diseases Group and the Acute Leukemia Group of the European Organization for Research and Treatment of Cancer (EORTC). “Empiric versus pre-emptive antifungal strategy in high-risk neutropenic patients on fluconazole prophylaxis: a randomized trial of the European organization for Research and Treatment of cancer (EORTC 65091)”, 2022, Clinical Infectious Diseases, in press
203. Tappe B., Lauruschkat C., Strobel L., Pantaleón García J., Kurzai O., Rebhan S., Kraus S., Pfeuffer-Jovic E., Bussemer L., Possler L., Held M., Hünniger K., Kniemeyer O., Schäuble S., Brakhage A., Panagiotou G., White L., Einsele H., Löffler J*., Wurster S*., “COVID-19 patients share common, corticosteroid- independent features of impaired host immunity to pathogenic molds”, 2022, Frontiers in Immunology 13:954985
204. Seif M., Kakoschke T., Ebel F., Bellet M., Trinks N., Renga G., Pariano M., Romani, L., Tappe B., Espie D. Donnadieu E., Hünniger K., Häder K., Sauer M., Damotte D., Alifano M., White L., Bachx M., Nerreter T., Machwirth M., Kurzai O., Prommersberger S., Einsele H., Hudecek M., Löffler J., “CAR T cells targeting Aspergillus fumigatus are effective at treating invasive pulmonary aspergillosis in preclinical models”, 2022, Science Translational Medicine, in press
205. Morton O., Griffiths J., Loeffler J., Orr S., White L., “Defective antifungal immunity in patients with COVID-19“, 2022, Frontiers in Immunology, in press
206. Griffiths J., Orr S., Morton O., Loeffler J., White L., „Host Biomarkers for the Diagnosis of Invasive Fungal Disease“, 2022, Journal of Fungi, in press
207. Häder A., Schäuble S., Gehlen J., Thielemann N., Buerfent B., Schüller V., Hess T., Wolf T., Schröder J., Weber M., Hünniger K., Löffler J., Vylkova S., Panagiotou G., Schumacher J.,, Kurzai O., “Pathogen-specific innate immune response patterns are distinctly affected by genetic diversity”, 2023, Nature Communications, in press
208. Cruciani M., White L, Barnes R., Loeffler J., Donnelly P., Rogers T., Heinz W., Warris A., Morton O., Lengerová M., Klingspor L., Sendid B., Lochkart D. „An overview of systematic reviews of Polymerase Chain Reaction (PCR) for the diagnosis of invasive aspergillosis in immunocompromised people: A FPCRI (Fungal PCR Initiative) study“, 2023, Journal of Fungi, in press